Main description:

Oligomerization in Health and Disease: From Enzymes to G Protein-Coupled Receptors, Volume 169 in the Progress in Molecular Biology and Translational Science series, provides in-depth reviews on topics of exceptional scienti?c importance. Topics of note in this new release include Computational prediction and re-design of aberrant oligomerization, Oligomerization of G protein-coupled receptors: an historical overview, Prediction and targeting of GPCR oligomer interfaces, GPCR Oligomerization dynamics: Functional consequences, GPCR heteromerization in neuropsychiatric disorders, Structural basis of regulation and oligomerization of human cystathionine ss-synthase, and Oligomerization of Porphobilinogen Synthase.

Contents:

1. Fluorescence microscopy methods for the study of protein oligomerization Roberto Arturo Petazzi, Amit Koikkarah Aji and Salvatore Chiantia 2. Computational prediction and redesign of aberrant protein oligomerization Jaime Santos, Valentin Iglesias and Salvador Ventura 3. Porphobilinogen synthase: An equilibrium of different assemblies in human health Eileen K. Jaffe 4. Prediction and targeting of GPCR oligomer interfaces Carlos A.V. Barreto, Salete J. Baptista, Antonio Jose Preto, Pedro Matos-Filipe, Joana Mourao, Rita Melo and Irina Moreira 5. Integrated structural modeling and super-resolution imaging resolve GPCR oligomers Francesca Fanelli, Aylin C. Hanyaloglu and Kim Jonas 6. Exploring functional consequences of GPCR oligomerization requires a different lens Kyla Bourque, Jace Jones-Tabah, Dominic Devost, Paul B.S. Clarke and Terence E. Hebert 7. Continuing challenges in targeting oligomeric GPCR-based drugs Joaquin Botta, Julia Appelhans and Peter J. McCormick 8. Adenosine A2A-dopamine D2 receptor-receptor interaction in neurons and astrocytes: Evidence and perspectives Diego Guidolin, Manuela Marcoli, Cinzia Tortorella, Guido Maura and L. Francesco Agnati 9. Genetic variants in dopamine receptors influence on heterodimerization in the context of antipsychotic drug action Faron-Gorecka Agata, Kusmider Maciej, Solich Joanna, Gorecki Andrzej and Dziedzicka-Wasylewska Marta 10. Oligomerization of G protein-coupled receptors: Still doubted? Sergi Ferre, Francisco Ciruela, Vicent Casado and Leonardo Pardo