Main description:

Organ Specific Drug Delivery and Targeting to the Lungs provides up to date information on the multidisciplinary field of particle engineering and drug delivery to the lungs, including advancements of nanotechnology. The text presents a unique, pragmatic focus with case studies, that help translate scientific understanding to practical implementation. In addition to highlighting the successful case studies, it also offers practical advice on watchouts, limitations, and 'bookend' boundaries involved in the stages of testing and development.

Additional Features Include:

Provides an account of particle engineering, discovery, biology, development, and delivery in relation with the advancements of nanotechnology, unlike any previous book.

Brings together the leading experts and researchers in the field to critically assess and discuss various topics influencing drug delivery.

Highlights the interplay of different scientific disciplines and the balance of requirements that are critical to molecule and product design.

With the strategic focus on what matters during new product development, this book provides a guide to understanding and navigating new drug discovery and development for lung targets.

Contents:

Chapter 01

Estimating Clinically Relevant Measures of Inhaled Pharmaceutical Aerosol Performance with Advanced In Vitro and In Silico Methods

Chapter 02

In Vitro Assessment of Drug Release, Dissolution, and Absorption in the Lung

Chapter 03

Lung-on-a-Chip and Lung Organoid Models

Chapter 04

Interaction between Inhalable Nanomedicines and Pulmonary Surfactant

Chapter 05

Particle engineering for pulmonary drug delivery

Chapter 06

Particle Architectonics for Pulmonary Drug Delivery

Chapter 07

Engineered Particles for Aerosolisation and Lung Deposition

Chapter 08

Recent advances in inhalable nanomedicine for lung cancer therapy

Chapter 09

Thin-Film Freeze-Drying Process for Versatile Particles for Inhalation Drug Delivery

Chapter 10

Nanoparticles as specific drug carriers

Chapter 11

Surface modification of micronized drug particles for aerosolization

Chapter 12

Spray Dried Particles for Inhalation

Chapter 13

Inhalation Aerosol Phospholipid Particles for Targeted Lung Delivery

Chapter 14

Nebulizers

Chapter 15

Protein and Peptide Delivery to the Lung via Inhalation

Chapter 16

Exosomes Based Drug Delivery for Lung Cancer Treatment