Main description:

This book discusses recent developments in several laboratories studying leishmaniasis. Sequencing of the human genome, as well as of the leishmania genome, has led to significant advances in our understanding of host-immune responses against leishmania, and mechanisms of infection-induced pathology, which is responsible for morbidity and mortality. Pathogenesis of Leishmaniasis focuses on the latest basic research into leishmaniasis, but also addresses how advances in understanding can be applied to prevention, control and treatment of what the WHO has classified a neglected tropical disease.

Contents:

Mechanisms of immunopathology of leishmaniasis.- Update on Leishmania mediators that promote immune evasion.- Paratransgenic Control of Leishmaniasis: New Developments.- Current status and future challenges for the development of Genetically Altered Live Attenuated Leishmania vaccines.- Reservoir control strategies for Leishmaniasis: past, present and future.- Treatment modalities for cutaneous and visceral leishmaniasis.