Main description:

Rubin and Damjanov's latest volume of Pathology Reviews highlights the latest progress in the interface of biology and disease. Forefront techniques and experimental models that were once considered exotic or esoteric, are explored here in the context of understanding more fully the processes involved in human disease. Topics include: regulation of liver growth * contractile cells in lungs * mineral formation in bone * folate metabolism * the "riddle of the mast cell" * HLA antigens * interleukin 6 * IgA nephropathy * Goodpasture syndrome * anti-basement membrane glomerulonephropathy * molecular mechanisms of oncogenesis * molecular diagnosis of cancer * inhibition of intercellular communication in carcinogenesis * DNA repair and its pathogenetic implications * human and rat mammary tumorigenesis. Pathology Reviews * 1990 is essential reading for everyone concerned with the mechanisms of disease.

Contents:

Cell and Metabolic Disorders. Regulation of Liver Growth: Protooncogenes and Transforming Growth Factors. Mechanism of Mineral Formation in Bone. Contractile Cells in Normal and Fibrotic Lungs. Role of Folate Binding Proteins in Folate Metabolism. New Clues for Solving the 'Riddle of the Mast Cell':: Microenvironmental Regulation of Mast Cell Development and Phenotypic Heterogeneity. Inflammation and Immunity. HLA Class II Polymorphism. Interleukin 6: A Multifunctional Cytokine Regulating Immune Reactions and the Acute Phase Protein Response. IgA Nephropathy: Pathogenesis of the Most Common Form of Glomerulonephritis. Goodpasture Syndrome: Molecular Architecture and Function of the Basement Membrane Antigen. Pathogenesis of Anti-Basement Membrane Glomerulopathy and Immune Complex Glomerulonephritis: Dichotomy Dissolved. Tumor Biology. Molecular Mechanisms of Oncogenesis. DNA Repair and Its Pathogenetic Implications. Molecular Diagnosis of Human Cancer. Role of Inhibition of Intercellular Communication in Carcinogenesis. Comparative Study of Human and Rat Mammary Tumorigenesis. Index.