Main description:

This monograph contains the proceedings of an International Symposium on the Pathophysiology of Cere- bral Energy Metabolism which was held at the University of Belgrade School of Medicine, September 19-22, 1977. The purpose of the symposium was to promote an interdisciplinary discussion on energy demand in the brain in pathophysiological states, particularly with regard to cessation of blood flow, epilepsy, and para- doxical sleep disturbances. Doctors W. F. Caveness, I. Klatzo, B. B. Mrsulja, Lj. M. Rakie, and v. Susie served as an advisory board and helped to plan the sci- entific program. The papers which were presented covered neurophysiological, neurochemical, morphological, and clinical approaches to the topics. The Editors v CONTENTS Introductory Remarks 1 J. Ristic Pathophysiology of Cerebral Ischemia * * * * * * 5 K. -A. Hossmann The Interpretation of Ultrastructural Abnormalities in Cerebral Ischemia 19 J. H. Garcia, A. S. Lossinsky, K. Donger, and F. C. Kauffman Short-Term Unilateral Ischemia in Gerbils: A Reevaluation ***** 33 N. Murakami, W. D. Lust, A. B. Wheaton, and J. V. Passonneau Some New Aspects of the Pathochemistry 47 of the Post-Ischemic Period * * * * * B.
B. Mrsulja Blood Flow, Oxygen, and Electrical Dynamics in Cerebral Ischemia 61 R. Cohn, B. J. Sussman, I. Klatzo, and J. F. Turman Cytochemistry of Hippocampus Following 73 Cerebral Ischemia * * ** ***** B. J. Mr~ulja, M. Spatz, and I.

Contents:

Introductory Remarks.- Pathophysiology of Cerebral Ischemia.- The Interpretation of Ultrastructural Abnormalities in Cerebral Ischemia.- Short-Term Unilateral Ischemia in Gerbils: A Reevaluation.- Some New Aspects of the Pathochemistry of the Post-Ischemic Period.- Blood Flow, Oxygen, and Electrical Dynamics in Cerebral Ischemia.- Cytochemistry of Hippocampus Following Cerebral Ischemia.- Cerebral Water and Electrolyte Content Following Ischemia and Blood-Brain Barrier Disturbances.- Behavior of the Blood-Brain Barrier (BBB) in Cerebral Ischemia.- Reemphasis of the Role of 5-Hydroxytryptamine in Cerebral Ischemia.- Brain Monoamines in Cerebral Infarction and Coma.- Transport Phenomena in Cerebral Ischemia.- Energetics, Thermal Sensitivity, and Tolerance Mechanisms of Brain Synaptosomes: A Comparative Study.- Biochemical Aspects of Cerebral Edema.- Significance of Adenylate Cyclase in the Regulation of the Permeability of Brain Capillaries.- Brain Microvessels: Glucose Metabolizing Enzymes in Ischemia and Subsequent Recovery.- Non-Invasive Measurement of Regional Cerebral Blood Flow in Patients with Cerebrovascular Disorders.- Energy Metabolism in Focal Seizures.- Some Biochemical Aspects of Electroconvulsive Seizure.- Initiation, Propagation, and Arrest of Seizures.- Some Mechanisms of Epileptic Activity Generalization.- The Influence of Serotonin on Seizure Susceptibility in the Gerbil.- Antiepileptic Drugs: Pharmacology and Mechanisms of Action.- Mechanism of Action of Phenytoin: Evidence for a Cerebellar Locus.- Biorhythmic Aspects of Epileptic Manifestations.- REM Sleep Deprivation: Effects on Incorporation of Inorganic Sulfate into Brain Acid Mucopolysaccharides.- Regional Cerebral Blood Flow in Man During Different Stages of Wakefulness and Sleep.- Polygraphically Measured Effects of Different Antidepressants.- Participants.