Main description:

Master the design and operation of perfusion cell cultures with this authoritative reference. Discover the current state-of-the-art in the design and operation of continuous bioreactors, with emphasis on mammalian cell cultures for producing therapeutic proteins. Topics include the current market for recombinant therapeutic proteins, current industry challenges and the potential contribution of continuous manufacturing. Provides coverage of every step of process development and reactor operation, including small scale screening to lab-scale and scale-up to manufacturing scale. Illustrated through real-life case studies, this is a perfect resource for groups active in the cell culture field, as well as graduate students in areas such as chemical engineering, biotechnology, chemistry and biology, and to those in the pharmaceutical industry, particularly biopharma, biotechnology and food or agro industry.

Contents:

1. Perfusion mammalian cell culture for recombinant protein manufacturing; 2. Perfusion bioreactors; 3. Scale-down models and sensors for process development; 4. Design and optimization of mammalian cell perfusion cultures; 5. Clinical and commercial-scale reactors; 6. Mechanistic and statistical modeling of bioprocesses.