Main description:

This book gives a detailed yet clear insight into the current state of the art of the therapeutic application of bacteriophages in different conditions. The authors bring in their practical expertise within their respective fields of expertise and provide an excellent overview of the potential and actual use of phage therapy. Topics like economic feasibility compared to traditional antibiotics and also regulatory issues are discussed in far detail.

This new volume is therefore a valuable resource for individuals engaged in the medical application of novel phage therapies.

Contents:

I. Bacteriophages as antibacterialagents

1. MaiaMerabishvili, Jean-Paul Pirnay, Kilian Vogele, Danish J. Malik;Production of PhageTherapeutics and Formulations - InnovativeApproaches.

2. ShigenobuMatsuzaki, JumpeiUchiyama;Phagepharmacokinetics: relationship with administrationroute.

3. ShawnaMcCallin, Frank Oechslin;BacterialResistance to Phage and itsImpact on Clinical Therapy.

II. Bacteriophages and the immune system

4. Jonas D. Van Belleghem, Krystyna Dabrowska, Mario Vaneechoutte, Jeremy J. Barr;Phageinteraction with the mammalianimmune system.

5. Maciej Zaczek, Marzanna Lusiak-Szelachowska, Beata Weber-Dabrowska, Ryszard Miedzybrodzki, Wojciech Fortuna, Pawel Rogoz, Slawomir Letkiewicz, Andrzej Gorski;Humoralimmuneresponse to phage-basedtherapeutics.

III.Use of bacteriophages to combat bacterial infections

6. JeromeGabard, Patrick Jault; How to achieve a goodphage therapy clinical trial?

7. RandallKincaid: Treatment and Prevention of BacterialInfectionsusingBacteriophages;Perspectives on the RenewedInterest in the United States.

8. PawelRogoz, Derek F. Amanatullah, RyszardMiedzybrodzki, Robert Manasherob, Nina V. Tikunova, Beata-Weber-Dabrowska, Wojciech Fortuna, SlawomirLetkiewicz, Andrzej Gorski; Phage Therapy in Orthopaedic Implant-associated Infections.

9. Katarzyna Kosznik-Kwasnicka, Gracja Topka, Aleksandra Dydecka, Agnieszka Necel, Bozena Nejman-Falenczyk, Sylwia Bloch, Grzegorz Wegrzyn, Alicja Wegrzy; The use of bacteriophages in animalhealth and food protection.

10. PetarKnezevic, VericaAleksicSabo;Combiningbacteriophages with otherantibacterialagents to combatbacteria.

11. Luis D. R. Melo, Diana Priscila Pires, Rodrigo Monteiro, JoanaAzeredo;"Phage therapy of infectious biofilms: Challenges and strategies".

IV. Phage therapy - regulatory and ethical aspects

12. Roger D. Plaut, Scott Stibitz; Regulatory Considerations for Bacteriophage Therapy Products.

13. EricPelfrene,ZigmarsSebris, Marco Cavaleri; Developing phagesintomedicines for Europe.

14. Daniel De Vos, Gilbert Verbeken, JohanQuintens, Jean-Paul Pirnay;Phagetherapy in Europe: Regulatory and intellectualpropertyprotectionissues.

15. Jan Borysowski, Andrzej Gorski;Ethics of phagetherapy.

V. Bacteriophage-derived antibacterial agents

16. Vincent A. Fischetti, PhageLysins;NovelAlternative to Antibiotics.