Main description:

Phycotoxins: Chemistry and Biochemistry presents the mostupdated information available on phycotoxins. Major emphases aregiven to chemistry and biochemistry, while minor emphases are givento the aspects of origin, toxicology, or analytical methodology.The book discusses 16 phycotoxins, 7 on those affecting the nervoussystems, 4 affecting other body systems; and 4 with undefinedtargets.

An alphabetical listing of toxins presented includes:Azaspiracids; Brevetoxins; Cyanobacterial toxins; Domoic acid;Gambierols; Gymnodimines, prorocentrolides, spirolides, pinnatoxinsand cyclic imines in general; Maitotoxin; Okadaic acid anddinophysistoxins; Palytoxins and ostreocins; Pectenotoxins;Polycavernosides; and Yessotoxins. In addition, several mechanisticaspects of newer or emerging toxins are covered such as amphidinolsor gymnocine. Information presented and coverage of each toxinfollows the following distribution: background and toxicology(10%); chemistry, biochemistry and metabolism (75%); mechanism ofaction (10%); and analytical methodology (5%).

The detailed information on chemistry in Phycotoxins:Chemistry and Biochemistry provides investigators, regulators,food technologists and toxicologists an updated basis on whichresearch in other areas such as toxicology, mechanism of action,analytical methodology and pharmacology can be successfullydeveloped and expanded.

Back cover:

Phycotoxins: Chemistry and Biochemistry presents the mostupdated information available on phycotoxins. Major emphases aregiven to chemistry and biochemistry, while minor emphases are givento the aspects of origin, toxicology, or analytical methodology.The book discusses 16 phycotoxins, 7 on those affecting the nervoussystems, 4 affecting other body systems; and 4 with undefinedtargets.

An alphabetical listing of toxins presented includes:Azaspiracids; Brevetoxins; Cyanobacterial toxins; Domoic acid;Gambierols; Gymnodimines, prorocentrolides, spirolides, pinnatoxinsand cyclic imines in general; Maitotoxin; Okadaic acid anddinophysistoxins; Palytoxins and ostreocins; Pectenotoxins;Polycavernosides; and Yessotoxins. In addition, several mechanisticaspects of newer or emerging toxins are covered such as amphidinolsor gymnocine. Information presented and coverage of each toxinfollows the following distribution: background and toxicology(10%); chemistry, biochemistry and metabolism (75%); mechanism ofaction (10%); and analytical methodology (5%).

The detailed information on chemistry in Phycotoxins:Chemistry and Biochemistry provides investigators, regulators,food technologists and toxicologists an updated basis on whichresearch in other areas such as toxicology, mechanism of action,analytical methodology and pharmacology can be successfullydeveloped and expanded.

Contents:

1. Gambierols (Makoto Sasaki, Eva Cagide, and Carmen Louzao).

2. Brevetoxins: Structure, Toxicology and Origin (Ambrose Furey,Keith O Callaghan, Javier García Fernández, MaryLehane, Mónica Fernández Amandi, and Kevin J. James).

3. Chemistry of Maitotoxin (Masayuki Satake).

4. Biochemistry of Maitotoxin (Laura A. de la Rosa, EmilioAlvarez–Parrilla, and Alejandro Martínez).

5. The Chemistry of Palytoxins and Ostreocins (PanagiotaKatikou).

6. Biochemistry of Palytoxins and Ostreocins (Carmen Vale andIsabel R. Ares).

7. Chemistry of Cyanobacterial Neurotoxins Anatoxin–a:Synthetic Approaches (Nuria Armesto Arbella, KeithO Callaghan, Ambrose Furey, and Kevin J. James).

8. Anatoxin–a and Analogues: Discovery, Distribution andToxicology (Kevin J. James, Janet Crowley, Mary Lehane, and AmbroseFurey).

9. Pectenotoxins (Christopher Miles).

10. Chemistry, Orgins and Distribution of Yessotoxin and itsAnalogues (Philipp Hess and John A.B. Aasen).

11. Pharmacology of Yessotoxin (Amparo Alfonso and CarmenAlfonso).

12. Chemistry of Diarrhetic Shellfish Poisoning Toxins (PauloVale).

13. The Molecular and Integrative Basis to Domoic Acid Toxicity(John Ramsdell).

14. Hepatotoxic Cyanobacteria (Ana Gago).

15. Polycavernosides (Leo A. Paquette and Mari Yamashita.

16. Structural Assignment and Total Synthesis of Azaspiracid–1(K.C. Nicolaou, Michael O. Frederick, Kevin P. Cole, GoranPetrovic, and Eriketi Loizidou).

17. Biochemistry of Azaspiracid Poisoning Toxins (NataliaVilariño).

18. The Cyclic Imines: An Insight into this Emerging Group ofBioactive Marine Toxins (Jordi Molgo and Emmanuelle Girard, andEvelyne Benoit).

Index.