Main description:

Polycyclic aromatic hydrocarbons, many of which have been identified as potent human carcinogens, occur widely in the environment as a result of incomplete combustion of fossil fuels and other organic matter. Major sources of emissions arise from wood and coal burning, automobiles, heat and power plants, and refuse burning. Their widespread occurrence in the air and in food and water underlines the importance of understanding their role as causes of human cancer. This 1991 volume was the first to review the chemical properties of these carcinogens and to relate their carcinogenic activity to their metabolic by-products within the body. The emphasis throughout is on those recent findings, newer methods and techniques which helped to illuminate the process of carcinogenesis. The volume is suitable for anyone with a professional interest in the chemistry and metabolism of polycyclic aromatic hydrocarbons, environmental chemistry and chemical carcinogenesis.

Contents:

Preface; 1. Nomenclature; 2. Environmental occurrence and cancer; 3. Structure-activity relationships; 4. Metabolic activation, DNA binding, and mechanisms of carcinogenesis; 5. Molecular properties of polyarenes; 6. Chemical reactivity; 7. General synthetic methods; 8. Alterant tetracyclic polyarenes; 9. Alterant pentacyclic polyarenes; 10. Alternant hexacylic polyarenes; 11. Nonalternant polyarenes; 12. Arene oxides and imines; 13. Dihydrodiols; 14. Diol epoxides; 15. Other oxidized metabolites; Index.