Main description:

The book is the first major review of menopause-associated osteoporosis, post WHI. The book has in-depth sections on the pathogenesis, epidemiology, and diagnosis of osteoporosis. The chief focus is on medical prevention and treatment, and includes chapters on hormone replacement therapy, bisphosphonates, selective estrogen receptor modulators (SERMs), vitamin D derivatives, calcium supplements, androgens, and tibolone.

Contents:

The Nature of Osteoporosis: Magnitude and Impact of Osteoporosis and Related Fractures. GONADAL STEROIDS & THE PATHOGENESIS OF OSTEOPOROSIS. Peptide Hormones and Osteocyte Growth Factors. Steroids as Regulators of Osteoblastic Function. Steroids and the Regulation of Osteoclastic Bone Resorption. Calcium and Vitamin D: Regulation of Mineral Homeostasis. EPIDEMIOLOGY. Genetic Determinates of Bone Mass. Bone Mineral Acquisition During Infancy and Adolescence. Style of Life, Physical Activity and Nutritional Factors. Postmenopausal Osteoporosis and Dental Health. DIGNOSIS. Bone Densitometry and Radiology. Assessment of Bone Quality. Clinical, Hormonal and Biochemical Evaluation.
New Techniques for the Non-Invasive Assessment of Bone Quality. Bone Ultrasound. PHARMACOLOGICAL PREVENTION AND RELATED TREATMENTS. Awareness of Osteoporosis and Related Treatments. Intervention Thresholds for Osteoporosis. Vitamin D and Calcium Supplements. Oral Contraceptives: Bone Effects in Fertile Age and Perimenopausal Women. Hormone Replacement Therapy. Selective Estrogen Receptor Modulators. Bisphosphonates. Phytoestrogens: Foods Or Drugs? Bone-Forming Agents. Tibolone. Conclusions. Bibliographies & Index