Main description:

There is a world-wide epidemic on obesity. This epidemic is driving the immense proportions of Type 2 diabetes across the globe. While there are numerous therapies for treating Type 2 diabetes, the most effective therapy is prevention. Prevention of Type 2 diabetes can be achieved properly by simultaneous prevention of obesity. Prediabetes, or metabolic syndrome, is the period between simple obesity and diabetes, and this critical period needs to be identified in a more consistent and systematic manner by clinicians worldwide. Clinical trials have indicated that diabetes prevention can be achieved by lifestyle changes and also by certain medications, though none are yet approved for use in prevention. On the other hand, there are funding agencies such as the NIH, CDC, and State Institutions that are interested in studying the prevention paradigms in different communities and ethnic minorities who are most prone to this epidemic. For these reasons, this title by renowned physician-scientist Derek LeRoith is both timely and vitally important for academic physicians, practitioners, allied health care providers, analysts, community activists, and all others interested in this increasing epidemic. This book provides a unique and comprehensive synthesis of the prevention and early diagnosis of Type 2 Diabetes, focusing on identifying risk factors and then moving into topics that address how to prevent their progression to full-blown diabetes. The difficult task of changing patients' behavior is given special emphasis. The chapters in this practical volume are written by a wide range of international experts, reflecting the editor's distinguished, internationally renowned career. The volume is organized in eight sections: an introduction to the overall issue of prevention, definitions of values based on ADA guidelines, pathophysiology, discussion of a range of interventional trials regarding prevention, and an overview of state-of-the-art clinical management approaches. Comprehensive and timely, Prevention of Type 2 Diabetes: From Science to Therapy is an essential reference for those treating and researching Type 2 Diabetes.

Contents:

01.Prevention of Type 2 Diabetes; from Science to Therapies: Introduction - Emily Jane Gallagher, Derek LeRoith

02.Pathophysiology: Loss of ss-cell function - Ele Ferrannini, Andrea Mari

03.Pathophysiology of Insulin Resistance: Implications for Prevention - Shamsa Ali, Vivian A. Fonseca

04.Epidemiology Including Youth through Adulthood & Socioeconomic Impact - Helen Looker

05.Prediabetes Genes in Pima and Amish - Leslie J. Baier

06.Predicting Diabetes - Rachel Danker, Jesse Roth

07.Screening for Prediabetes and Diabetes - Amir Tirosh

08.Neuropathy in pre-Diabetes and the Metabolic Syndrome - Aaron I. Vinik, Marie-Laure Nevoret

09.Interventional Trials to Prevent Diabetes: Diabetes Prevention Program - Vanita R. Aroda, Robert E. Ratner

10.Decreasing Postprandial Plasma Glucose in Subjects with IGT by Using an (alpha)-Glucosidase Inhibitor for the Prevention of Type 2 Diabetes Mellitus: The STOP-NIDDM Trial - Jean-Louis Chiasson, Markku Laakso, and Markolf Hanefeld

11.Da Qing, Finnish DPP, Tripod and Dream: Lifestyle and Thiazolidinediones in the Prevention of Diabetes - Mariela Glandt, Zachary Bloomgarden

12.Community Approaches to Diabetes Prevention - Ann Albright, David Williamson

13.Think Locally, Act Locally, Extend Globally: Diabetes Prevention Through Partnerships with Local Communities - Carol R. Horowitz, Brett Ives

14.Global Challenge in Diabetes Prevention from Practice to Public Health - Peter E.H. Schwarz