Main description:

Primer on Multiple Sclerosis was developed to provide a comprehensive overview of the clinical and basic science aspects of MS. It is designed to be of practical use to clinical neurologists, and addresses all of the major issues that may occur in the management of persons with MS. The reader is provided with the latest information on the science of MS, including immunology, genetics, epidemiology and pathology, as well as a summary of the newest directions
in basic science research. Guidelines for diagnosis and appropriate use of diagnostic modalities are presented. All clinical aspects of MS are discussed, including extensive information on aspects that may be more challenging for the neurologist to manage, such as sleep disorders and pain.

Disease modifying therapies, including those that are FDA approved, as well as off label and experimental therapies are discussed. Finally, there are chapters on employment and legal issues, as well as an overview of clinical trials and clinical trial outcome measures, which are helpful in reviewing the scientific literature in these areas.

Contents:

Contributors

Chapter 1: The History of Multiple Sclerosis: From the Age of Description to the Age of Therapy
T. Jock Murray
Part 1: Basic Science

Chapter 2: Genetics and Epidemiology in Multiple Sclerosis
Sreeram V. Ramagopalan and A. Dessa Sadovnick

Chapter 3: Neurophysiology of Multiple Sclerosis
Jefferson C. Slimp

Chapter 4: Immunology of Multiple Sclerosis
Laura Piccio and Anne H. Cross

Chapter 5: Taking a Microscopic Look at Multiple Sclerosis
Claudia F. Lucchinetti
Part 2: Diagnosis and Prognosis

Chapter 6: Diagnosis of Multiple Sclerosis
Loren A. Rolak

Chapter 7: Neuroimaging in Multiple Sclerosis
Nancy L. Sicotte

Chapter 8: Cerebrospinal Fluid Profile Supporting a Clinical Definite Multiple Sclerosis Diagnosis
Wallace W. Tourtellotte

Chapter 9: Evoked Potentials
Marc R. Nuwer

Chapter 10: Temporal and Clinical Course of Multiple Sclerosis
Erica Grazioli, Cornelia Mihai, and Bianca Weinstock-Guttman

Chapter 11: Outcome Measures in Multiple Sclerosis
Robert M. Herndon
Part 3: Clinical Manifestations

Chapter 12: Neuro-Ophthalmologic Manifestations of Multiple Sclerosis
Erik V. Burton and Elliot M. Frohman

Chapter 13: Disorders of Mobility in Multiple Sclerosis
Thomas E. McNalley and Jodie K. Haselkorn

Chapter 14: Multiple Sclerosis and Pain
Norman S. Namerow

Chapter 15: Management of Urinary and Bowel Dysfunction in Patients with Multiple Sclerosis
Ja-Hong Kim

Chapter 16: Assessment and Treatment of Sexual Dysfunction in Multiple Sclerosis
Frederick W. Foley

Chapter 17: Gender and Reproductive Issues in Multiple Sclerosis
Rhonda Voskuhl

Chapter 18: Cerebellar and Brainstem Dysfunction in Multiple Sclerosis
Angeli S. Mayadev and George H. Kraft

Chapter 19: Cognitive Impairment and Mood Disturbances
Nicholas G. LaRocca

Chapter 20: Fatigue in Multiple Sclerosis
Christopher Christodoulou, Yashma Patel, and Lauren Krupp

Chapter 21: Sleep Disorders in Multiple Sclerosis
Tiffany Braley and Alon Y. Avidan

Chapter 22: Pediatric Multiple Sclerosis
E. Ann Yeh, Tanuja Chitnis, Lauren Krupp, Jayne M. Ness, Dorothee E. Chabas, Nancy Kuntz, and Emmanuelle L. Waubant
Part 4: Therapeutics

Chapter 23: Immunomodulatory Agents for Relapsing-Remitting Multiple Sclerosis
Lawrence M. Samkoff

Chapter 24: Immunosuppressive and Novel Therapies
Barbara S. Giesser

Chapter 25: Complementary and Alternative Medicine in Multiple Sclerosis
Allen C. Bowling
Part 5: Psychosocial Issues

Chapter 26: Living with Multiple Sclerosis: The Psychosocial Challenges for Patients and Their Families Rosalind C. Kalb

Chapter 27: Employment and Career Development Considerations
Phillip D. Rumrill, Jr. and Steven W. Nissen

Chapter 28: Legal Planning Issues
Laura D. Cooper, Esq.
Part 6: Research

Chapter 29: Issues in the Design and Interpretation of Multiple Sclerosis Clinical Trials
Stephen Krieger, Svenja Oynhausen, and Aaron Miller

Chapter 30: Basic Science in Multiple Sclerosis: Progress and Promise
Wendy Gilmore and Leslie P. Weiner

Index