Main description:

Protein phosphorylation via protein kinases is an inevitable process that alters physiological and pathological functions of the cells. Thus, protein kinases play key roles in the regulation of cell life or death decisions. Protein kinases are frequently a driving factor in a variety of human diseases including aging and cellular senescence, immune system and endothelial dysfunctions, cancers, insulin resistance, cholestasis and neurodegenerative diseases, as well as bacterial resistance in persistent infections. Recent developments in quantitative proteomics provide important opinions on kinase inhibitor selectivity and their modes of action in the biological context. Protein Kinase-mediated Decisions Between Life and Death aims to have the reader catch insights about up-to-date opinions on "Protein Kinases" related pathways that threaten human health and life. As "Protein Kinases" are related to many health problems, clinicians, basic science researchers and students need this information.
Chapter "Signal Transduction in Immune Cells and Protein Kinases" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Contents:

Chapter Title

Corresponding Author

Protein kinase-mediated decision between life and death

Atilla ENGIN

Aging, cellular senescence and protein kinases

Ayse Basak ENGIN

ERK1/2 MAP kinase, its regulation and role in cellular activities including apoptosis and cell survival

Imran ALI

Signal transduction in immune cells and protein kinases

Monica NEAGU

Role of protein kinase C in immune cell activation and its implication chemical-induced immunotoxicity

Emanuela CORSINI

Metabolic stress and immunity

Dietmar FUCHS

Two-component signal transduction systems in antibiotic resistance

Evren Doruk ENGIN

Oxidative stress-related endothelial cell death and protein kinases

Atilla ENGIN

Protein kinase inhibitors in traumatic brain injury and repair

Hari SHARMA

Activation of tropomyosin-related kinase receptor B by N-acetyl-serotonin: implications for neuroprotection

Gregory OXENKRUG

Glucolipotoxicity-related beta cell death and protein kinases

Atilla ENGIN

Amyloid beta toxicity in Alzheimer's Disease and neuronal death-associated protein kinases

Ayse Basak ENGIN

Protein kinases and cell death in hematological disorders

Ibrahim C. HAZNEDAROGLU

A crosstalk between dual-specific phosphatases and dual-specific protein kinases can be a potential therapeutic target for anti-cancer therapy

Basak CELTIKCI

Bile acid toxicity and protein kinases

Atilla ENGIN

Nanoparticle toxicity: Protein kinases and cell death

Ayse Basak ENGIN