Main description:

Psychiatric Pharmacogenomics is a book written to help clinicians to use pharmacogenomic testing to improve the pharmacotherapy that they provide for their patients. It is designed to teach clinicians how to order pharmacogenomic tests and interpret the results. Clinical examples are used to underscore the specific indications for pharmacogenomic testing and to clarify the clinical usefulness of identifying atypical genotypes that result in problematic responses to
medication.

The first section of the book begins with a basic review of molecular genetics. Additionally, the book also includes an extensive glossary of technical terms associated with molecular genetics and pharmacogenomics. The clinical utility of pharmacogenomic testing is demonstrated throughout the book by describing the implications of genetic variations for the care of individual patients.

The second section of the book is organized into fourteen chapters that each focus on the clinical implications of testing for specific genes for which variants have been associated with either therapeutic response or side effects of psychotropic medications. Each of these chapters is structured in the same manner and involves a description of the gene and its significant variants. Each chapter also includes one or more clinical vignettes.

The third section of the book discusses the clinical usefulness of pharmacogenomic testing, ethical issues associated with pharmacogenomic testing, and provides predictions for the future development of more sophisticated pharmacogenomic testing.

Contents:

Table of Contents

I. Basic Foundations

Introduction

Chapter 1 - The Language of Molecular Genetics

Chapter 2 - The Fourteen Genes

Chapter 3 - The Problem and the Solution

II. The Drug Metabolizing Enzyme Genes

Chapter 4 - The Cytochrome P450 2D6 Gene

Chapter 5 - The Cytochrome P450 2C19 Gene

Chapter 6 - The Cytochrome P450 2C9 Gene

Chapter 7 - The Cytochrome P450 1A2 Gene

III. A Gene Associated with the Metabolism of Neurotransmitters

Chapter 8 - The Catechol-O-Methyltransferase Gene

IV. The Neurotransmitter Transporter Genes

Chapter 9 - The SLC6A2 Norepinephrine Transporter Gene

Chapter 10 - The SLC6A3 Dopamine Transporter Gene

Chapter 11 - The SLC6A4 Serotonin Transporter Gene

V. The Serotonin Receptor Genes

Chapter 12 - The Serotonin 1A Receptor Gene

Chapter 13 - The Serotonin 2A Receptor Gene

Chapter 14 - The Serotonin 2C Receptor Gene

VI. The Dopamine Receptor Genes

Chapter 15 - The Dopamine D2 Receptor Gene

Chapter 16 - The Dopamine D3 Receptor Gene

Chapter 17 - The Dopamine D4 Receptor Gene

VII. Clinical Considerations

Chapter 18 - The Clinical Utility of Psychiatric Pharmacogenomic Testing

Chapter 19 - Ethical Issues to Consider When Using Pharmacogenomic Testing in Psychiatric Practice

Chapter 20 - Future Development of Psychiatric Pharmacogenomic Testing

Glossary of Genetic and Pharmacogenomic Terms

Generic and Brand Names of Pharmacogenomically Relevant Drugs

Index