Main description:

This book describes radionanomedicine as an integrated medicine using exogenous and endogenous This book describes radionanomedicine as an integrated approach that uses exogenous and endogenous nanomaterials for in vivo and human applications. It comprehensively explains radionanomedicine comprising nuclear and nanomedicine, demonstrating that it is more than radionanodrugs and that radionanomedicine also takes advantage of nuclear medicine using trace technology, in which miniscule amounts of materials and tracer kinetic elucidate in vivo biodistribution.

It also discusses exogenous nanomaterials such as inorganic silica, iron oxide, upconversion nanoparticles and quantum dots or organic liposomes labelled with radioisotopes, and radionanomaterials used for targeted delivery and imaging for theranostic purposes. Further, it examines endogenous nanomaterials i.e. extracellular vesicles labelled with radioisotopes, known as radiolabelled extracellular vesicles, as well as positron emission tomography (PET) and single photon emission computed tomography (SPECT), which elucidate the biodistribution and potential for therapeutic success.

Contents:

Exogenous Radionanomedicine

- Inorganic Nanomaterials Weibo Cai (U Wisconsin, USA)

- Organic Nanomaterials: Radioliposome, Albumin, Dendrimer, Polymer (PLGA, etc). Keon Wook Kang (Seoul Nat'l U, Korea)

Endogenous Radionanomedicine

- Extracellular Vesicles Yong Song Gho (POSTECH)

- Radiolabelling Hong Yoon Choi &

Do Won Hwang (Seoul Nat'l U)

- Biodistribution and Imaging Hong Yoon Choi & Dong Soo Lee (SNU, Korea)

- Validation of Therapeutic Potential Dong Soo Lee (SNU, Korea)

Surface modification and Radiolabeling

- Surface modification Hao Hong (U Michigan, USA)

- Radiolabeling method: Core/Surface labelling, Chemical and Physical labelling, Jonathan F Lovell (U Buffalo) or Jae Min Jeong (SNU Korea)

- Click chemistry

Yun-Sa

ng Lee

(SNU) &

amp; Dexing Zeng (U Pittsburgh)

Targeted Delivery with Click Chemistry

- Targeting molecule and nano-platform Yun-Sang Lee (SNU, Korea)

- Preservation of ligand functionality by click chemistry

- Bart Cornelissen (U Oxford, UK)

- Bioorthogonal reaction Dong Wook Kim (Inha U, Korea) &nbs

p;

&n

bsp; &n

bsp;

In vivo Biodistribution using PET and SPECT

- Preclinical PET/CT, SPECT/CT, and PET/MRI

- Hyung Jun Im (U Wisconsin) & Gi Jeong Cheon (SNU Korea)

- Tracer kinetic Jae Sung Lee & Dong Soo Lee (SNU, Korea)

Factors and Results Affecting Biodistribution

- Size, charge and shape

- PEGylation and the similar Mailander (U Mainz, Germany)

- &nbs

p; Corona and its consequences Kenneth Dawson (U Dublin, Ireland)

- Excretion and clearance Hyung Jun Im & Dong Soo Lee (SNU Korea)

Immune Responses to Nanomaterials

- IgM responses Ishida (U Tokushima, Japan)

- Innate Immunity Bengt Fadeel (Karolinska University, Sweden)

- CARPA Szebeni (Semmelweiss U, Hungary)

Molecular Imaging

Dong Soo Lee (SNU, Korea)