Main description:

This book devotes a chapter to each RTK family and the multiple receptors within each family, thoroughly covering all of the RTKs. The chapters all follow the same structure, presenting this essential information in an accessible and user-friendly format. Each chapter covers one specific family of receptors and begins with a general introduction to that family and a comprehensive discussion of that receptor's family in development and human disease. Following are in-depth analyses of each family's receptors with discussions on the gene, protein, ligands, activation, and signaling pathways along with discussion of receptor processing and signal attenuation. Further, cross talk with other receptors systems, post-translational modification and specific unique characteristics to each RTK are discussed. Because it isolates and explains each family, this book is an essential companion volume to Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease, by the same authors, which talks about RTKs more generally and without the family-by-family detail.

Contents:

Anaplastic Lymphoma Kinase (ALK) Receptor Tyrosine Kinase (RTK) Family.- The TAM Receptor Family.- DDR Receptor Tyrosine Kinase Family.- EGFR/ERBB Receptor Tyrosine Kinase Family.- Eph Receptor Tyrosine Kinase Family.- Receptor Tyrosine Kinase textbook - Fibroblast Growth Factor Receptor (FGFR).- Insulin/IGF1 Receptors (INSR/IGF1R) Family.- MET Receptor Tyrosine Kinase Family.- MuSK Receptor Family.- The PDGFR Receptor Family.- PTK7 Receptor Tyrosine Kinase Family.- RET Receptor Tyrosine Kinase.- ROR Receptor Tyrosine Kinase Family.- ROS1 Receptor Tyrosine Kinase.- The RYK Receptor Tyrosine Kinase Subfamily.- TIE Receptor Tyrosine Kinase Family.- TRK Receptor Family.- The VEGF Family of Ligands and Receptors.- NOK Receptor Tyrosine Kinase Family.