Main description:

This fascinating volume addresses the processes and mechanisms taking place in the cell during meiosis and recombination. It covers multicellular eukaryotes such as Drosophila, Arabidopsis, mice and humans. Once per life cycle, mitotic nuclear divisions are replaced by meiosis I and II - reducing chromosome number from the diploid level to a haploid genome, reshuffling the homologous chromosomes by their centromeres, and recombining chromosome arms by crossing-over.

Contents:

Meiotic Crossing-Over and Disjunction: Overt and Hidden Layers of Description and Control.- Chromatid Cores in Meiotic Chromosome Structure and Segregation.- Sister Chromatid Cohesion and Centromere Organization in Meiosis.- Spo11 and the Formation of DNA Double-Strand Breaks in Meiosis.- Synapsis, Double-Strand Breaks, and Domains of Crossover Control in Drosophila Females.- Synaptic and Recombination Nodules in Mammals: Structural Continuity with Shifting Protein Composition.- Human Recombination Hotspots: Before and After the HapMap Project.- Meiotic Nondisjunction-The Major Cause of Trisomy 21.- Meiosis in Arabidopis thaliana: Recombination, Chromosome Organization and Meiotic Progression.- Modified Cell Cycle Regulation in Meiosis.