Main description:

This book provides an overview of the types, sources, and applications of stem cells in regenerating various ocular tissues, with a perspective on both potential applications of stem cells and possible challenges. The scope of the chapters include both preclinical and clinical applications, including stem cell-derived therapies based on endogenous tissue repair; stem cell transplantation and cell replacement therapy; gene therapy; and in vitro disease modelling. Additionally, the volume presents applications in both anterior and posterior ocular disease, with a particular focus on diseases of the ocular surface, cornea, limbus, and retina, including inherited retinal dystrophies as well as acquired diseases, such as age-related macular degeneration. Regenerative Medicine and Stem Cell Therapy for the Eye is an ideal book for advanced researchers in stem cell and ocular biology as well as clinical ophthalmologists, and will be of interest to readers with backgrounds in developmental biology and bioengineering.
This book also

Skillfully reviews cutting-edge advances in stem cell biology as applied to regenerative medicine and ocular disease

Provides expert viewpoints on key hurdles and challenges to successful implementation of stem cell-derived therapies in the clinical domain

Offers a multi-disciplinary, broad understanding of cell-based therapies for ocular diseases by incorporating perspectives from biomedical scientists, physicians, and engineers

Examines the connection between cell therapy and gene editing, in particular relation to ocular disease

Contents:

1. Photoreceptor cell replacement therapy from stem cells2. Human Pluripotent Stem Cells as In Vitro Models for Retinal Development and Disease3. Clinical Applications of Limbal Stem Cells for Regenerative Medicine4. Bioengineered and Regenerative Medicine Strategies for Retina Repair5. Stem Cell Therapy and Regenerative Medicine in the Cornea6. Overview of Cells and Animal Models use for Retinal Stem Cell Research7. Limbal stem cells and the treatment of limbal stem cell deficiency8. Retinal ganglion cell replacement - A bridge to the brainIndex