Main description:

Regenerative medicine is the main field of
groundbreaking medical development and therapy using knowledge from developmental and
stem cell biology, as well as advanced
molecular and cellular techniques. This collection of volumes on Regenerative Medicine: From
Protocol to Patient, aims to explain the scientific knowledge and emerging
technology, as well as the
clinical application in different organ systems and diseases. International
leading experts from all over the world describe the latest scientific and
clinical knowledge of the field of regenerative medicine. The process of translating
science of laboratory protocols into therapies is explained in sections on regulatory,
ethical and industrial issues. This collection is organized into five volumes: (1) Biology of
Tissue Regeneration, (2) Stem Cell Science and Technology, (3) Tissue Engineering,
Biomaterials and Nanotechnology, (4) Regenerative Therapies I, and (5) Regenerative
Therapies II. The textbook gives the student, the researcher, the health care professional,
the physician and the patient a complete survey on the current scientific
basis, therapeutical protocols, clinical translation and practiced therapies in regenerative
medicine.

Volume 1 contains eleven chapters addressing the latest basic science knowledge on the "Biology
of Tissue Regeneration". The principles of cell regeneration control by extracellular
matrix and the biology of stem
cell niches are explained. Depicted are the principles of
molecular mechanisms controlling asymmetric cell division, stem cell differentiation,
developmental and regenerative biology, epigenetic and genetic control as well as
mathematical modelling for cell fate prediction. Regenerative biology of stem cells in the central nervous and cardiovascular systems leading to complex tissue
regeneration in the model species axolotl and zebrafish, as well as the impact of immune signalling on nuclear reprogramming are
outlined. These up to date accounts gives the readers advanced insights into the
biological principles of the regenerative processes in stem cells, tissues and
organisms.

Contents:

1 Extracellular matrix and tissue regeneration

Zygmunt Mackiewicz, Yrjoe Tapio
Konttinen, Emilia Kaivosoja, Vasily Stegajev, Hanoch Daniel Wagner, Jaakko
Levon and Veli-Matti Tiainen

2 Stem cell niche

Chenhui Wang, Jun Chen, Pei Wen, Pei Sun and Rongwen Xi

3 Stem cells and asymmetric cell division

Rita Sousa-Nunes and Frank Hirth

4 Stem cells in the developing and adult nervous system

Fumitaka Osakada and Masayo Takahashi

5 Epigenetic mechanisms regulating the transition from embryonic stem cells
towards a differentiated neural progeny

Marijn Schouten, Nik Papaloukas, Pascal Bielefeld, Silvina A. Fratantoni and
Carlos P. Fitzsimons

6 Mathematical models in stem cell differentiation and fate predictability
Wayne M. Eby and Natalia Coleman

7 Organ and appendage regeneration in the axolotl

Johanna E Farkas, Piril Erler, Polina D Freitas, Alexandra Sweeney, and James R
Monaghan

8 Development and regeneration of the vertebrate brain

Brian Key

9 Role of innate immune signaling in nuclear reprogramming

Shu Meng, Palas Chandaand John P. Cooke

10 Cardiac regeneration in zebrafish

Chi-Chung Wu and Gilbert Weidinger

11 Genetics and regeneration in vertebrates

Elizabeth Denise Hutchins and Kenro Kusumi

Index