Main description:

Regulation of Downstream Targets, Volume 134 in the Advances in Protein Chemistry and Structural Biology series, presents interesting chapters on topics such as Transcriptional regulatory mechanisms and signaling networks in Viral Infections, Identification of potential key genes associated with pathogenesis and prognosis of endometrial cancer based on Integrated Bioinformatics Approaches, Differential regulation of genes in stage IB pancreatic cancer associated with increased risk of metastasis, AMPK-related LKB1-downstream targets, A compilation of bioinformatic approaches to identify novel downstream targets for the detection and prophylaxis of cancer, Protein phosphatases and their targets: Critical determinants of signaling pathway in plants, and more.

Other sections cover Calcium decoders and their targets: The holy alliance that regulate cellular responses, Importin alpha family NAAT/IBB domain: functions of a multi-faceted long chameleon sequence, Aurora Kinase A and related downstream molecules: A Potential Network for Cancer Therapy, Emerging Role of Heat Shock Proteins in Cardiovascular Diseases, Function, Structure, Evolution, Regulation and Drug Target Relevance of Arylalkylamine N-acetyltransferase, and Analysis of signaling cascades from myeloma cells treated with pristimerin.

Contents:

1. Transcriptional regulatory mechanisms and signalling networks in Viral Infections
Selvaraj Chandrabose Sr.
2. Identification of potential key genes associated with pathogenesis and prognosis of endometrial cancer based on Integrated Bioinformatics Approaches.
George Priya Doss C
3. Differential regulation of genes in stage IB pancreatic cancer associated with increased risk of metastasis
George Priya Doss C
4. AMPK-related LKB1-downstream targets
Ilana Chefetz Menaker
5. A compilation of bioinformatic approaches to identify novel downstream targets for the detection and prophylaxis of cancer
Ajaikumar B. Kunnumakkara
6. Protein phosphatases and their targets: Critical determinants of signaling pathway in plants
Girdhar Kumar Pandey
7. Calcium decoders and their targets: The holy alliance that regulate cellular responses
Girdhar Kumar Pandey
8. Importin alpha family NAAT/IBB domain: functions of a multi-faceted long chameleon sequence
Noriko Yasuhara
9. Aurora Kinase A and related downstream molecules: A Potential Network for Cancer Therapy
Hifzur R. Siddique
10. Emerging Role of Heat Shock Proteins in Cardiovascular Diseases
Nitish Mahapatra
11. Function, Structure, Evolution, Regulation and Drug Target Relevance of Arylalkylamine N-acetyltransferase
Qian Han
12. Analysis of signaling cascades from myeloma cells treated with pristimerin
Hatem Zayed, Shilpa Kuttikrishnan, Manoj Kumar Kashyap, Shahab Uddin and George Priya Doss C