Main description:

This book presents new and noteworthy research into retinal diseases.

It focuses on what we currently know about the environment, genetics and mechanisms that lead to retinal degenerations, new diagnostics, and innovative therapeutic modalities to preserve vision. Written by renowned scientific investigators, this innovative collection of treatment strategies and technological discoveries allows for the realistic translation of research into practice.

Contents:

Retinal Degenerations: Genetics, Progression, and Therapeutics - Table of Contents

J Tombran-Tink and CJ Barnstable (eds)
University of Missouri-Kansas City and Yale University School of Medicine

1. Living with Retinal Degeneration
Coping with Retinitis Pigmentosa: A Patientis View
Gordon Cousins and James Cape

2. Degenerative Diseases of the Retina
Epidemiology of ARMD Early in the 21st Century
Jie Jin Wang, Paul Mitchell and Ronald Klein

3. Leber Congenital Amaurosis: Biology, Diagnostics, and Therapeutics
Robert K. Koenekoop

4. Macular Degeneration. Aging Changes and Novel Therapies
Peter E. Liggett and Alejandro J. Lavaque

5. Stargardt Disease: from gene discovery to therapy
Rando Allikmets

6. X-Linked Juvenile Retinoschisis
Bernhard H.F. Weber and Ulrich Kellner

7. Retinal Degeneration in Usher Syndrome
David S. Williams

8. Mouse models of RP
Bo Chang, Norman L. Hawes, Muriel T. Davisson, J.R. Heckenlively

9. Mechanisms underlying retinal degenerations
The Impact of Diabetes on Neuronal, Glial and Vascular Cells of the Retina: Implications for the Pathogenesis of Diabetic Retinopathy
Sylvia B. Smith

10. Statins and Age-Related Maculopathy
Gerald McGwin Jr. and Cynthia Owsley

11. The role of Drusen in Macular Degeneration and New Methods of Quantification
R. Theodore Smith and Umer F. Ahmad

12. RPE lipofuscin: Formation, Properties, and Relevance to Retinal Degeneration
Janet R. Sparrow

13. Genetic Modifiers that Affect Phenotypic Expression of Retinal Diseases
Malia M. Edwards, Dennis M. Maddox, Jungyeon Won, Jrgen K. Naggert and Patsy M. Nishina

14. X-linked retinal dystrophies and microtubular functions within the retina
Alan Wright and Xinhua Shu

15. Synaptic Remodeling in RetinalDegeneration
You-Wei Peng and Fulton Wong

16. Developing Therapeutic Strategies for Retinal Degenerative Diseases
On The Suppression of Photoreceptor Cell Death in Retinitis Pigmentosa
Fiona Kernan, Alex G. McKee, G. J. Farrar and Peter Humphries

17. Cell-based therapies to restrict to progress of photoreceptor degeneration
Raymond D. Lund and Shaomei Wang

18. Current Status of IPE Transplantation and its Potential as a Cell-Based Therapy for Age-Related Macular Degeneration and Retinal Dystrophies
Makoto Tamai

19. Recent results in Retinal Transplantation give hope for restoring vision
Robert B. Aramant, Norman D. Radtke and Magdalene J. Seiler

20. Stem Cells and Retinal Transplantation
Joanne Yau, Henry Klassen, Tasneem Zahir and Michael Young

21. Application of Encapsulated Cell Technology for Retinal Degenerative Diseases
Weng Tao and Rong Wen

22. Effective treatment for the canine RPE65 null mutation, a hereditary retinal dystrophy comparable to human Leberis Congenital Amaurosis
Kristina Narfstrm, Gregory E. Tullis and Mathias Seeliger

23. The Use of Neuroprotective Factors in Retinal Degenerations
Joyce Tombran-Tink and Colin Barnstable

24. Carbonic anhydrase inhibitors as a possible therapy for RP17, an Autosomal Dominant Retinitis Pigmentosa associated with the R14W mutation, apoptosis, and the unfolded protein response.
George Rebello, Jacquie Greenberg and Raj Ramesar