Main description:

Hepatocyte and Kupffer Cell Interactions presents a comprehensive discussion of historical and recent information regarding this diverse field of research. The role of Kupffer cells and hepatoctyes in normal physiology, nonseptic pathological states, and in sepsis is examined. Microanatomy and methods of experimental study are covered as well. In each of the book's chapters, the role of the Kupffer cell and hepatocyte interaction is placed in context with information on particular liver functions or disease states.
Hepatocyte and Kupffer Cell Interactions is an essential reference for leukocyte specialists, gastroenterologists, immunologists, and other researchers working in this fascinating field.

Contents:

Section 1 - The Normal Liver: 1. The Origin of Kupffer Cells and Their Anatomic Relationship to Hepatocytes 2. Modes of Communication between Kupffer Cells and Hepatocytes Under Normal and Pathological Conditions 3. Experimental Models for Studying the Interaction of Kupffer Cells and Hepatocytes Section 2 - Nonseptic pathologic States: 4. Antitumor Defense System of the Liver 5. Alcohol-Induced Liver Disease 6. Viral Infections and Hepatitis 7. Role of Macrophages and Endothelial Cells in Hepatotoxicity 8. Liver Alloimmunity 9. Nonparenchymal Cell and Hepatocyte Interaction in Antimalarial Activity: A Central Role for Nitric Oxide Section 3 - The Liver in Sepsis: 10. Regulation of Kupffer Cell Activation 11. The Role of Kupffer Cells in Control of Acute Phase Protein Synthesis 12. The Changes in Hepatic Lipid and Carbohydrate Metabolism in Sepsis