Main description:

Searching for a Mechanism traces the history of cell bioenergetics from the early notions of science in the Enlightenment through to the end of the twentieth century. Author John N. Prebble's treatment of this history falls into five periods, from the 1600's to the present day. The "bioenergetics revolution" has long been overlooked because it occurred simultaneously as the other major biological revolution of the twentieth century: the development of
molecular biology. This book aims to provide the first thorough history of bioenergetics. The story of cell bioenergetics is primarily concerned with the synthesis of ATP (adenosine triphosphate), sometimes referred to as the energy currency of the cell. In fact the term 'bioenergetics' was probably not introduced
into the field until Albert Szent-Gyorgyi published a small book under that title in 1957.

Despite the twentieth century focus of the subject matter, the history of this field commences with the work of those in the seventeenth century who sought to understand the process of breathing and passes through metabolic biochemistry concluding with the elucidation of the molecular mechanisms of key enzymes in bioenergetics. Although the story of metabolic biochemistry (which is often taken to include bioenergetics) essentially belongs to the twentieth century, progress in this area cannot
be understood without recourse to previous centuries. Thus from the seventeenth century onwards it is possible to trace a path of early thinking which eventually laid the ground work for the dramatic success of twentieth century studies.

Contents:

Preface
Acknowledgements
Abbreviations

Chapter 1 Introduction: Respiration, Phosphorylation and Mechanism
Chapter 2 From Physiology to Biochemistry: Respiration and Oxidation, 1600 to 1900
Chapter 3 Relating Phosphorylation, Respiration and Oxidation, 1900-1945
Chapter 4: Emergence of the Field of Cell Bioenergetics, 1945-1960
Chapter 5: Defining the Mechanism, 1960-1977
Chapter 6: Discovering Photosynthesis
Chapter 7: Elucidating the Photosynthetic Light Reaction
Chapter 8: The Impact of Protein Technology, 1977-1997
Chapter 9: The Search for Mechanism

References
Index