Main description:

This comprehensive handbook on the implementation of short course radiotherapy for the treatment of breast cancer is intended as an up-to-date resource for the clinician. The book opens with a series of chapters on underlying principles and diverse relevant topics, including pathologic anatomy of early-stage breast cancer, radiobiology of accelerated breast irradiation, quality assurance and radiation safety, surgical considerations in partial breast irradiation, and impact of oncoplastic surgery on adjuvant radiotherapy. Individual sections are then devoted to hypofractionated whole breast radiotherapy, accelerated partial breast irradiation, and intraoperative radiotherapy. Each section includes details of patient selection, physics, techniques, data, and toxicity. The reader is provided with clear guidance on the appropriate use of accelerated forms of adjuvant radiotherapy for treatment of early-stage breast cancer and on various emerging treatment approaches.

Contents:

Section I:

1.Accelerated Breast Irradiation: History, Rationale, and Controversies

2.Pathologic Anatomy of Early-Stage Breast Cancer: Defining the Target

3.The Radiobiology of Accelerated Breast Irradiation

4.Quality Assurance and Radiation Safety/Medical Events

5.Surgical Considerations in Partial Breast Irradiation

6.Impact of Oncoplastic Surgery on adjuvant XRT

7. Comparison of true cost between modalities in a changing health care system

SECTION II: Hypofractionated WBI

8. Patient Selection

9. Physics of HWBI

10. Treatment History- techniques/data/toxicity

SECTION III: APBI

11. Patient Selection

12. Physics of Accelerated Partial Breast Irradiation

13. Interstitial brachytherapy - techniques/data/toxicity

14. Intracavitary brachytherapy - techniques/data/toxicity

15. 3D-Conformal external beam radiotherapy - techniques/data/toxicity

SECTION IV: IORT

16. Patient Selection

17. Physics of IORT

18. 50 kV Photons: Targeted Intraoperative Radiotherapy (TARGIT) - techniques/data/toxicity

19. Intraoperative Technique with Electrons- techniques/data/toxicity

SECTION V: Emerging treatment approaches

20. Extreme hypofractionation

(brachytherapy, Gammapod, UK FAST WBI)

21. APBI for breast augmentations

22. Accuboost

23. APBI for in-breast recurrence following WBI

24. Preoperative partial breast

25. Locoregional Hypofractionation SECTION VI: Hypofractionation for metastatic disease

26.Stereotactic treatment for Oligometastatic disease

27.Hypofractionaton for palliation

Bone mets - palliative

Visceral mets - palliative

Chest wall/localregional recurrence