Main description:

The only fully comprehensive reference for STAT proteins and their biology, this book describes the current state of ongoing research in this broad area, and looks toward the future to try to predict the discoveries that lie ahead.

Contents:

Foreword. Color Plates. 1. Introduction: a brief history of the STATs and a glance at the future; J.E. Darnell Jr. I: STAT Proteins and their Regulators. 2. The STAT protein family; M.H. Heim. 3. The Janus kinase protein family; P. Saharinen, O. Silvennoinen. 4. Structural bases of receptor-JAK-STAT interactions; P.C. Heinrich, et al. 5. SOCS proteins: negative regulators of the JAK/STAT pathway; R. Starr, D.J. Hilton. 6. The PIAS protein family and TC-PTP; Bin Liu, Ke Shuai. 7. Prime time for the Drosophila JAK/STAT pathway; E.A. Bach, N. Perrimon. 8. The STAT proteins of Dictyostelium; J.G. Williams. 9. JAK/STATs in zebrafish: conservation of JAK/STAT signaling in vertebrates; A.C. Oates, L.I. Zon. II: Mechanisms of Activation of and Transcriptional Regulation by STAT Proteins. 10. IFNs and STATs, an incestuous relationship; C. Schindler, Li Song. 11. Mechanisms and biological roles of STAT activation by the IL-6 family of cytokines; D. Kamimura, T. Hirano. 12. Growth hormone induced activation and regulation of JAK2 and STAT proteins; J.H. Kurzer, C. Carter-Su. 13. G protein-coupled-receptor mediated STAT activation; J.M. Rodriguez-Frade, et al. 14. Regulation of STATs by posttranslational modifications; T. Decker, et al. 15. Interactions of STATs with SRC family kinases; C.M. Silva, et al. 16. The role of phosphatases and reactive oxygen species in regulation of the JAK/STAT pathway; A. Larner, M. David. 17. Raft-STAT signaling and transcytoplasmic trafficking; P.B. Seghal. 18. Nuclear trafficking of STAT proteins; K.M. McBride, N. Reich. 19. Interaction of STAT signals with other signaling pathways; D.R. Wesemann, G.M. Fuller. 20. Forward genetics in mammalian cells; E.S. Kandel, G.R. Stark. 21. X-ray crystal structure of STAT proteins and structure-activity relationships; C.W. Muller, et al. 22. STAT transcriptional activation mechanisms: communication with the basal transcriptional machinery; D.E. Levy. 23. STST-dependent gene expression without tyrosine phosphorylation; M. Chattergee-Kishore, et al. III: Biological Impact of STAT Activation. 24. JAK/STAT signaling: a tale of jeeps and trains; A.P. Costa-Pereira, et al. 25. Viruses and STAT proteins: co-evolution with the JAK-STAT pathway; C.M. Ulane, C.M. Horvath. 26. STATs in immune responses to viral infections; C.A. Biron, et al. 27. IFN receptor-STAT1 signaling and cancer immunoediting; R. Uppaluri, et al. 28. STAT activation in TH1/TH2 differentiation; T.L. Murphy, K.M. Murphy. 29. Mechanisms and biological consequences of STAT signalling by cytokines that share the common cytokine receptor chain C; Jian-Xin Lin, W.J. Leonard. 30. STAT activation in the acute phase response; H. Baumann. 31. STAT3 function in vivo; V. Poli, T. Alonzi. 32. Tissue-specific function of STAT3; K. Takeda, S. Akira. 33. Role of STATs in the biological functions o