Main description:

The sirtuin family of proteins (SIRT1-7) received a lot of attention in recent years as they serve as metabolic sensors that control not only metabolism, but also aging and lifespan regulation. As such, sirtuins are strong targets for the treatment of age-related metabolic diseases, including obesity, diabetes, and cancer. Indeed, many research groups as well as pharmaceutical companies discovered food components and/or drugs that target the sirtuins and provide significant health benefits. This book focuses on various aspects of sirtuin biology, from basic biochemistry, via molecular function, to its role in (fighting) human disease.

Contents:

General introductionRiekelt H. Houtkooper
Biochemistry and Enzymology of SirtuinsYue Yang and Anthony A. Sauve
NAD+ as a pharmacological tool to boost sirtuin activityRiekelt H. Houtkooper
Protein lysine acylation: abundance, dynamics and functionOlga Pougovkina and Vincent C. J. de Boer
SIRT1 in metabolic health and diseaseMarie Boutant and Carles Canto
Deacetylation by SIRT3 relieves inhibition of mitochondrial protein function Peter Chhoy, Kristin A. Anderson, Kathleen A. Hershberger, Frank K. Huynh, Angelical S. Martin, Eoin McDonnell, Brett S. Peterson, Laura A. Starzenski, Donald S. Backos, Kristofer S. Fritz, and Matthew D. Hirschey
SIRT5 reveals novel enzymatic activities of sirtuinsBin He and Hening Lin
Diverse roles for SIRT6 in mammalian healthspan and longevityBernadette M. M. Zwaans, William Giblin and David B. Lombard
Sirtuins in cancer - emerging role as modulators of metabolic reprogrammingJaewon J. Lee, Karina N. Gonzalez Herrera and Marcia C. Haigis
Sirtuins as metabolic modulators of muscle plasticityKeir Menzies, Julien Francisco Zaldivar-Jolissaint and Johan Auwerx
Sirtuins and agingCarles Canto and Riekelt Houtkooper
Sirtuins and the Circadian Clock: Epigenetic and Metabolic Crosstalk Selma Masri, Marina Maria Bellet and Paolo Sassone-Corsi
Sirtuin activation by small moleculesHassina Massudi, Lindsay E. Wu, and David A. Sinclair
Future perspectiveBrian Kennedy
Index