Main description:

Skin Tissue Models provides a translational link for biomedical researchers on the interdisciplinary approaches to skin regeneration. As the skin is the largest organ in the body, engineered substitutes have critical medical application to patients with disease and injury - from burn wounds and surgical scars, to vitiligo, psoriasis and even plastic surgery. This volume offers readers preliminary description of the normal structure and function of mammalian skin, exposure to clinical problems and disease, coverage of potential therapeutic molecules and testing, skin substitutes, models as study platforms of skin biology and emerging technologies.

The editors have created a table of contents which frames the relevance of skin tissue models for researchers as platforms to study skin biology and therapeutic approaches for different skin diseases, for clinicians as tissue substitutes, and for cosmetic and pharmaceutical industries as alternative test substrates that can replace animal models.

Contents:

Section 1 - Therapeutic Molecules and Cosmetics Testing 1. Cosmetic industry requirements regarding skin models for cosmetic testing Christian Pellevoisin, Charbel Bouez, Jose Cotovio 2. Overall perspective on the clinical importance of skin models Yusef Yousuf, Saeid Amini-Nik, Marc G. Jeschke,

Section 2 - Skin Diseases: clinical demands and diseased-skin in vitro models 3. In vitro models of Melanoma Dagmar Kulms, Friedegund Meier 4. Organotypic and humanized animal models of genodermatoses Esteban Chacon-Solan, Sara Guerrero-Aspizua, Lucia Martinez-Santamaria, Marcela Del Rio, Fernando Larcher 5. In vitro models of Psoriasis Bryan Roy, Melissa Simard, Isabelle Lorthois, Audrey Belanger, Maxim Maheux, Alexandra Duque-Fernandez, Genevieve Rioux, Philippe Simard, Marianne Deslauriers, Louis-Charles Masson, Alexandre Morin and Roxane Pouliot 6. In vitro models of Vitiligo Muriel Cario-Andre, Katia Boniface, Francois-Xavier Bernard, Alain Taieb, Maria Lucia Dell'Anna, Julien Seneschal 7. In vitro models of squamous cell carcinoma Elizabeth Pavez Lorie, Hans-Jurgen Stark, Manuel Berning, Petra Boukamp

Section 3 - Skin Substitutes: Clinical demands and skin tissue equivalents 8. Strategies to promote the vascularization of skin substitutes after transplantation Jennifer Bourland, Julie Fradette 9. On the path to scarring-free skin regeneration approaches Mohammed Ashrafi, Adam Hague, Mohamed Baguneid, Teresa Alonso-Rasgado, Ardeshir Bayat 10. Pre-clinical Models for Wound Healing Studies Irena Pastar, Liang Liang, Andrew P Sawaya, Tongyu Cao Wikramanayake, George D Glinos, Stephan Drakulich, Vivien Chen, Olivera Stojadinovic, Stephen C Davis, and Marjana Tomic-Canic 11. The importance of targeting inflammation in skin regeneration Megan Schrementi, Lin Chen, Luisa Ann DiPietro

Section 4 - In Vitro Models as study platforms of skin Biology 12. In Vitro Models to study hair follicles generation Ana Korosec, Beate Maria Lichtenberger 13. In Vitro Models to study cutaneous innervation mechanisms Nicolas Lebonvallet, Christelle Le Gall-Ianotto, Jeremy Cheret, Raphael Leschiera, Matthieu Talagas, Raphaele Le Garrec, Virginie Buhe, Killian L'herondelle, Olivier Gouin, Mehdi Sakka, Nicholas Boulais, Ulysse Pereira, Jean-Luc Carre, Laurent Misery 14. Skin in vitro models to study dermal white adipose tissue role in skin healing Manuela E. L. Lago, Mariana T. Cerqueira, Rogerio P. Pirraco, Rui L. Reis, Alexandra P. Marques 15. Immunocompetent in vitro skin models Victoria Hutter, Stewart B Kirton, David YS Chau

Section 5 - Emerging technologies for the development of 3D skin models 16. Additive manufacturing in the development of 3D skin models Kelsey Retting, Deborah G. Nguyen 17. Induced Pluripotent Stem Cells Potential to generate skin tissue models Olga Kashpur, Avi Smith, Nailia Mukhamedshina, Jeremy Baskin, Yulia Shamis, Kyle Hewitt, Behzad Gerami-Naini, Jonathan A. Garlick 18. Requirements of skin tissue models for high throughput screening Stephanie H. Mathes, Christian N. Parker