Main description:

The phenomenon known as Leao's spreading depression is
investigated in this collection of ten original articles.
New ideas about the fundamental mechanisms, which focus on
the involvement of polyunsaturated fatty acids and free
radicals, are presented. The relationship of spreading
depression with clinical entities such as migraine,
epilepsy, ischemic and protein-deficiency conditions of the
nervous tissue are discussed as well. Studies dealing with
the application of non-invasive techniques to monitor the
disease are included.

Contents:

Spreading Depression: Some Reminiscences.- Cortical Spreading Depression as a Migraine Mechanism: Clinical and Experimental Aspects.- GABAergic Mechanisms Involved in Cortical Spreading Depression in Normal and Early Malnourished Rats.- Spreading Depression and Neuron Damage: a Brief Review.- Synergetics of Spreading Depression: Reentry Waves and Reverberators in the Rat Brain.- Recent Studies on Retinal Spreading Depression.- Magnetic and Impedance Measurements for the Detection of Spreading Depression at a Distance.- Interstitial Fluid pH and its Changes During Spreading Depression in Isolated Chick Retina.- Detection of Magnetic Fields from Isolated Avian Retina During Spreading Depression.- Thalamic and Hippocampal Spreading Depression: Electrophysiological and Behavioral Evidence.