Main description:

This volume will describe recent progress and future directions in radiation oncology and biology research, focusing on strategies designed to improve disease control and reduce the risk of long-term adverse effects on patients. As more and more patients are becoming long-term survivors, this strategy will become increasingly important--in radiation oncology and throughout the field of oncology.

Contents:

1. Mechanisms of Normal Tissue Response.- 2. The Role of Hypoxia in Radiation Response.- 3. The Role of Cancer Stem Cells in Tumour Radioresponse.- 4. Novel Strategies to Prevent, Mitigate or Reverse Radiation Injury and Fibrosis.- 5. Technology Based Strategies to Enhance the Therapeutic Ratio.- 6. Nitric Oxide Synthase Uncoupling in Tumor Progression and Cancer Therapy.- 7. Aiming the Immune System to Improve the Antitumor Efficacy of Radiation Therapy.- 8. The Role of MicroRNAs in modulating Tissue Response to Radiation.- 9. Adapting Therapy Based on Tumor Response.- 10. NQO1 Bioactivatable Drugs Modify Radiation Responses.- 11. DNA Repair Pathways as a Potential Target for Radiosensitization.- 12. Radiosensitizing Glioma by Targeting ATM with Small Molecule Inhibitors.