Main description:

In spite of their relatively low prevalence, systemic vasculitides have been the object of intensive basic and clinical investigations over the last few years. As a consequence, important advancements have been achieved: from updated diagnostic and classification criteria and a more rational nomenclature to the recognition of an expanding spectrum of clinical manifestations and potentially devastating complications; from the recognition of the viral etiology of conditions such as HCV-related cryoglobulinemic vasculitis and HBV-associated polyarteritis nodosa to newly named variable vessel vasculitis exemplified by Behcet's disease; from single-organ vasculitis such as central nervous system vasculitis to the more recently emerging features of the IgG4-related, immune-mediated diseases that are showing remarkable clinical heterogeneity. In addition, intriguing pathogenetic hypotheses are being reported for certain chronic, relapsing vasculitides that are improving our understanding of their biology and basic pathophysiology. New avenues are being explored that will hopefully allow a deeper comprehension of the relationships between certain virus-driven vasculitides and lymphoproliferation, and possibly lead to the identification of novel biomarkers that may be used to single out patients at an increased risk of relapse. This explosion of knowledge is obviously resulting in state-of-the-art, personalized treatments of systemic vasculitides.

This book is a collection of reviews on the major vasculitides, written by scientists and clinicians with a multi-year experience in this field. We hope it will provide the reader with a stimulating container of new advances in scientific knowledge and more rational therapeutic approaches to this fascinating chapter of pathology.

Contents:

SYSTEMIC VASCULITIDES: CURRENT STATUS AND PERSPECTIVES

Editors: Franco Dammacco, Domenico Ribatti, Angelo Vacca

Table of Contents

I. Biology of Blood Vessels, Experimental Models and Nomenclature of Vasculitides

Chapter 1

Morphofunctional Aspects of Endothelium

Domenico Ribatti (Bari, Italy)

Chapter 2

Animal Models of ANCA-Associated Vasculitis

Domenico Ribatti, Franco Dammacco (Bari, Italy)

Chapter 3

Nomenclature of Vasculitides: 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides and Beyond

J. Charles Jennette, Ronald J. Falk, Marco A. Alba (Chapel Hill, NC, USA)

Chapter 4

Search for Autoantibodies in Systemic Vasculitis: is it Useful?

Joice Belem, Bruna Saviol, Alexandre Wagner Silva de Souza (Sao Paul, Brasil)

Chapter 5

Pathogenic Role of ANCA in Small Vessel Inflammation and Neutrophil Function Giuseppe A. Ramirez, Angelo A. Manfredi (Milan, Italy)

II. Primary Systemic Vasculitides

Chapter 6

Takayasu Arteritis: When Rarity Maintains the Mystery

Enrico Tombetti, Elena Baldissera, Angelo A. Manfredi, Maria Grazia Sabbadini (Milan, Italy)

Chapter 7

Takayasu Arteritis and Ulcerative Colitis: A Frequent Association?

Chikashi Terao (Boston, MA, USA)

Chapter 8

Giant Cell Arteritis

Silvia Laura Bosello, Elisa Gremese, Angela Carbonella, Federico Parisi, Francesco Cianci, Gianfranco Ferraccioli (Rome, Italy)

Chapter 9

HLA System and Giant Cell Arteritis

F. David Carmona, Javier Martin (Granada, Spain)

Chapter 10

Microscopic Polyangiitis

Franco Dammacco, Angelo Vacca (Bari, Italy)

Chapter 11

Granulomatosis with Polyangiitis (Wegener's)

Franco Dammacco, Sebastiano Cicco, Domenico Ribatti, Angelo Vacca (Bari, Italy)

Chapter 12

Eosinophilic Granulomatosis with Polyangiitis (Churg Strauss Syndrome)

Renato Alberto Sinico, Paolo Bottero (Milan, Italy)

Chapter 13

ANCA-Associated Vasculitis and the Mechanisms of Tissue Injury

Adrian Schreiber, Mira Choi (Berlin, Germany)

Chapter 14

Long-Term Outcome of ANCA-Associated Systemic Vasculitis

James Ritchie, Timothy Reynolds, Joanna Robson (Bristol, U.K.)

Chapter 15

Kawasaki Disease: Past, Present and Future

Fernanda Falcini, Gemma Lepri (Florence, Italy)

Chapter 16

Polyarteritis Nodosa

Nicolo Pipitone, Carlo Salvarani (Reggio Emilia, Italy)

Chapter 17

Anti-Glomerular Basement Membrane Disease

Michele Rossini, Annamaria Di Palma, Vito Racanelli, Franco Dammacco, Loreto Gesualdo (Bari, Italy) Chapter 18

IgA Vasculitis

Roberta Fenoglio, Dario Roccatello (Turin, Italy)

Chapter 19

Systemic Vasculitis and Pregnancy

Maria Grazia Lazzaroni, Micaela Fredi, Sonia Zatti, Andrea Lojacono, Angela Tincani (Brescia, Italy)

Chapter 20

Behcet Disease

Rosaria Talarico, Stefano Bombardieri (Pisa, Italy)

Chapter 21

Small Vessel Vasculitis of the Skin

Robert G. Micheletti (Philadelphia, PA, USA)

Chapter 22

Adult Primary Central Nervous System Vasculitis

Carlo Salvarani, Robert D. Brown, Jr, Caterina Giannini, Gene G. Hunder

(Reggio Emilia, Italy; Rochester, MN, USA)

Chapter 23

Diagnosis and Therapy of Peripheral Vasculitic Neuropathy

Franz Blaes (Gummersbach, Germany)

Chapter 24

Childhood Uveitis

Alice Brambilla, Rolando Cimaz, Gabriele Simonini (Florence, Italy)

Chapter 25

Cogan's Syndrome

Rosanna Dammacco (Bari, Italy)

Chapter 26

Non-Infectious Retinal Vasculitis

Shiri Shulman, Zohar Habot- Wilner (Tel Aviv, Israel)

Chapter 27

IgG4-Related Disease

Emanuel Della Torre (Milan, Italy)

Chapter 28

Urticarial Vasculitis. A Review of the Literature

Giulia De Feo, Roberta Parente, Chiara Cardamone, Massimo Triggiani (Salerno, Italy)

III. Secondary Vasculitides

Chapter 29

HCV-Related Cryoglobulinemic Vasculitis: an Overview

Franco Dammacco, Sabino Russi, Domenico Sansonno (Bari, Italy)

Chapter 30

Vasculitis In Connective Tissue Diseases

Patrizia Leone, Sebastiano Cicco, Angelo Vacca, Franco Dammacco, Vito Racanelli (Bari, Italy)

Chapter 31

Buerger's disease (Thromboangiitis Obliterans) Masayuki Sugimoto, Kimihio Komori (Nagoya, Japan)

Chapter 32

Cannabis-Associated Vasculitis

Anne Claire Desbois, Patrice Cacoub (Paris, France)

IV. Diagnostic and Therapeutic Advances of Systemic Vasculitides

Chapter 33

Imaging in systemic vasculitis

Mazen Abusamaan, Patrick Norton, Klaus Hagspiel, Aditya Sharma

(Charlottesville, VA, USA)

Chapter 34

Therapeutic use of biologic agents in systemic vasculitides

John Anthonypillai, Julian L. Ambrus Jr. (Buffalo, NY, USA)

Chapter 35

Treatment of ANCA-Associated Vasculitides

Loic Guillevin (Paris, France)