Main description:

The Systems Biology of Parkinson's Disease will be underpinned by new measurement techniques. This is particularly true of the pathology of Parkinson's Disease, where recent developments in brain imaging have offered new insights into the morphology of dopaminergic neurons that have profound implications for the special vulnerability and role of this class of neurons.

Contents:

Imaging of dopaminergic neurons and the implications for Parkinson's disease.- Modelling and simulation of brain energy metabolism: energy and Parkinson's disease.- Systems Biology of Aging: Opportunities for Parkinson's Disease.- Mitochondrion- and Endoplasmic Reticulum-Induced SK Channel Dysregulation as a Potential Origin of the Selective Neurodegeneration in Parkinson's Disease.- Energetics of Ion Transport in Dopaminergic Substantia nigra Neurons: ion exchange dynamics at the pacemaking membrane.- Real-time In Vivo Sensing of Neurochemicals.- Modeling protein and oxidative metabolism in Parkinson's disease.- Mathematical Models of Dopamine Metabolism in Parkinson's Disease.- Index.