Main description:

This volume will detail the current state and perspectives of autophagy-based cancer therapy. Covering a wide range of topics, it will include an overview of autophagy as a therapeutic target in cancer, autophagy modulators as cancer therapeutic agents, implications of micro-RNA-regulated autophagy in cancer therapy, modulation of autophagy through targeting PI3 kinase in cancer therapy, targeting autophagy in cancer stem cells, and roles of autophagy in cancer immunotherapy. In addition, the volume will review applications of system biology and bioinformatics approaches to discovering cancer therapeutic targets in the autophagy regulatory network.

The volume will be beneficial for a variety of basic and clinical scientists, including cancer biologists, autophagy researchers, pharmacologists, and clinical oncologists who wish to delve more deeply into this field of cancer research.

This volume will be the first book to focus solely on autophagy as a target in cancer therapy. As well, it will comprehensively discuss the roles of autophagy in most currently available cancer treatments.

Contents:

1. Autophagy as a Therapeutic Target in Cancer (Jenny Mae Samson and Andrew Thorburn)
2. Autophagy in Cancer Cells vs Cancer Tissues: two different stories (Chi Zhang, Tao Sheng, Sha Cao, Samira Issa-Boube, Tongyu Tang, Xiwen Zhu, Ning Dong, Wei Du, and Ying Xu)
3. Small-Molecule Regulators of Autophagy as Potential Anti-Cancer Therapy (Qing Li, Mi Zhou, and Renxiao Wang)
4. Regulation of autophagy by microRNAs: Implications in cancer therapy(Hua Zhu and Jin-Ming Yang)
5. Targeting PI3-kinases in modulating autophagy and anti-cancer therapy(Zhixun Dou and Wei-Xing Zong)
6. Adult and Cancer Stem Cells:Perspectives on Autophagic Fate Determinations and Molecular Intervention (Kevin Chen and Richard Caderone)
7. Role of autophagy in tumor progression and regression(Bassam Janji and Salem Chouaib)