Main description:

This book provides research-oriented care providers with up-to-date information on the oral cancer patient population, the ways in which we are treating them, and the scientific approaches being pursued in order to improve survival and reduce treatment-related morbidity. The text is organized into three sections covering epidemiology and management, cancer development and biomarkers, and breaking developments and novel approaches for drug discovery. The first section includes discussion of the emerging role of HPV in oral cancer and explains the surgical, chemotherapy and radiation approaches to treatment. Aspects such as molecular progression, the role of cancer stem cells in tumor development, and the value of various biomarkers are then examined. The final section is devoted to the latest advances and covers, among other topics, current clinical trials, emerging drug targets, and targeting of the unfolded protein response and of mediators of coagulation.

Contents:

Epidemiology and Management: Epidemiology.- Emerging Role of HPV.- Management of Oral Cancer. Development and Biomarkers: Molecular Progression and Signaling.- Stem Cells and Tumor Development.- Prognostic/Predictive Biomarkers.- EIF4e as Biomarker and Target. Breaking Developments and New Drug Discovery: Current Clinical Trials.- Emerging Drug Targets.- Targeting the UPR.- Targeting Meditators of Coagulation.- Resveratrol Pre-Sensitizing.- Academic High Throughput Drug Discovery.