Main description:

This book traces significant aspects of the history of immunology, exploring the immune system and immunodeficiency. The author recounts human hematopoietic development, and how a distinction of the immune system into thymus-dependent and thymus-independent components has been demonstrated in different animal species, including amphibians, birds, and mammals.

Other themes explored in this book include discoveries about the role of the thymus of the Bursa of Fabricius in the development of immunologic competence, and observations on the changes in the lymphoid organs after bursectomy and thymectomy in chickens. Readers will discover how the bursa provides a unique microenvironment for the proliferation and differentiation of B cells, while thymectomized and irradiated animals were deficient in lymphocytes that mediated inflammatory responses, as assessed by skin graft rejection, delayed-type hypersensitivity, and graft versus host reaction.

A clear perspective for understanding several diseases and also the entire lymphoid system emerges through the experiments and extensive histopathological studies of patients with primary immunodeficiency diseases that are described in these chapters.

Researchers in the life sciences, in biomedicine and the history of medicine will all find something of value in this highly engaging work. It will also appeal to those with an interest in public health and neurobiology.

Contents:

Contents

1. Introduction

2. Human hematopoietic development

2.1 The hemangioblast and the yolk sac

2.2 The aorta-gonad mesonephros

2.3 The fetal liver and the placenta

2.4 The bone marrow

3. The Bursa of Fabricius

3.1 The discovery of the Bursa of Fabricius and its structure

3.2 The Bursa of Fabricius plays a major role in the development of antibody-mediated immunity but bursectomy do not abrogate the antibody response to cellular antigens3.3 Immune globulin syntesis regulation

3.4 Mammalian "bursa-equivalent" organs and the role of liver and bone marrow in lymphopoiesis

4. The Thymus

4.1 The discovery of the thymus and its function

4.2 Studies of the thymus in the chick and in the mouse

4.3 The functional anatomy of the human thymus

4.4 The effects of neonatal thymectomy

4.5 The thymus is essential for normal development of the immune system

4.6 Removal of either the thymus or bursa of Fabricius

5. Clinical correlates

5.1 Immunodeficiencies

5.2 Di George syndrome

5.3 Thymoma with immunodeficiency

5.4 Severe combined immunodeficiencies and ataxia-teleangestasia

5.5 The role of thymus and of bursa equivalent organs in the development of

leukemia and other tumors

References