Main description:

Since the endothelium plays such an important role in the pathophysiology of the circulatory system, the readers attention is directed here towards the possible involvement of these polypeptides in the aetiology of ischaemic heart disease, cerebrovascular accidents, hypertension, atherosclerosis and renal failure.

Contents:

The Endothelium as a Regulator of Vascular Tone and Growth.- Effects of Physical and Pharmacological Interventions on Circulating Endothelin-1 Levels in Humans.- The Role of Endothelin in Congestive Heart Failure.- Endothelin as a Regulator of Vascular Tone in Man: Studies in Upper Limb Resistance and Capacitance Vessels.- Systemic and Endocrine Effects of Endothelin in Humans.- Endothelin in Hypertension and Vascular Hypertrophy: Experimental Studies.- Role of Endogenous Endothelin in Myocardial Ischemia and Nitric Oxide-Deficient Hypertension.- Endothelin and Renal Function: From Theory to Therapy.- The Endothelium and the Pathogenesis of Chronic Vascular Diseases: The Protective Role of Calcium Antagonists.- Insulin and the Regulation of the Cardiovascular System: Role of the L-arginine Nitric Oxide Pathway and the Sympathetic Nervous System.- Endothelin Receptor Antagonists as New Tools to Inhibit Endothelin induced Vasoconstriction in Humans: Comparison with Calcium Channel Blockers.- Endothelial Dysfunction: Clinical Applicability of Calcium Antagonist Drugs.- Endothelin in Hypertension and Diabetes Mellitus.- Endothelium-Dependent Vasodilation in the Peripheral Circulation in Humans In Vivo: Effects of Hypertension and Aging.- Endothelin and Pulmonary Hypertension.