Main description:

This open access volume will introduce recent discoveries in cancer metabolism since the publication of the first edition in 2018, providing readers with an up-to-date understanding of developments in the field.

Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, the authors delve into the complexity and diversity of cancer metabolism and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies for cancer treatment. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer treatment.

This book has four major parts. Part one will cover the basic metabolism of cancer cells, followed by a discussion of the heterogeneity of cancer metabolism in part two. Part three addresses the relationship between cancer cells and cancer-associated fibroblasts, and the new part four will explore the metabolic interplay between cancer and other diseases. This new section makes the book unique from other texts currently available on the market.

The second edition will be useful for cancer metabolism researchers, cancer biologists, epidemiologists, physicians, health care professionals in related disciplines, policymakers, marketing and economic strategists, among others. It may also be used in courses such as intro to cancer metabolism, cancer biology, and related biochemistry courses for undergraduate and graduate students.

Contents:

Part I. The Basic Metabolism of Cancer Cells

Chapter 1. Glucose Metabolism

Chapter 2. Glutamine Metabolism

Chapter 3. Heterogeneity of Cellular Lipid Metabolism in Cancer

Part II. The Heterogeneity of Cancer Metabolism

Chapter 4. The Multifaceted Metabolism of Glioblastoma

Chapter 5. The Intricate Metabolism of Pancreatic Cancers

Chapter 6. Breast Cancer Metabolism

Chapter 7. Non-Hodgkin's Lymphoma Metabolism

Chapter 8. The Metabolism of Renal Cell Carinomas

Chapter 9. The Metabolism of Liver Cancer

Chapter 10. Different Tumor Microenvironments Lead to Different Metabolic Phenotypes

Chapter 11. The Intratumoral Heterogeneity of Cancer Metabolism

Part III. Relationship of Cancer Cells and Cancer-Associated Fibroblasts

Chapter 12. Metabolic Relationship of Cancer Cells and Cancer-Associated Fibroblasts

Chapter 13. Targeting Metabolic Crosstalk Between Cancer Cells and Cancer-Associated Fibroblasts

Part IV. The Metabolic Interplay Between Cancer and Other Diseases

Chapter 14. Diabetes and Cancer Metabolism

Chapter 15. Neurological Diseases and Cancer Metabolism

Chapter 16. Cardiovascular Diseases and Cancer Metabolism

Chapter 17. Metabolism of Immune Cells