Main description:

The Hippo signaling pathway is rapidly gaining recognition as an important player in organ size control and tumorigenesis, and many leading scientists are showing increased interest in this growing field and it's relation to cancer. The chapters in this volume cover virtually all aspects of tumor biology, because members of the Hippo Pathway have been associated with numerous well-established cell signaling pathways, just to name a few; Ras, Wnt, TGFbeta and p53. Moreover, Hippo signaling is not solely involved in regulating "classic" tumor characteristics such as cell proliferation, survival and growth, but is also diversely involved in cell-autonomous and non-cell-autonomous differentiation, migration and organ size control. The primary audience are researchers interested in basic science in the areas of tumor suppression, cell cycle and size regulation, development and differentiation.

Contents:

Introduction.- Merlin and Angiomotin in Hippo-Yap signaling.- MST1/2 and other upstream signaling that affect Hippo pathway function.- YAP1 uses its modular protein domains and conserved sequence motifs to orchestrate diverse repertoires of signaling.- Regulation of YAP and TAZ transcription co-activators.- Regulation of YAP and TAZ by epithelial plasticity.- Hippo pathway and apoptosis.- YAP and p73: a matter of mutual specificity in tumour suppression.- The c-Abl/YAP/p73 apoptotic module and the Hippo pathway.- Hippo in cell cycle and mitosis.- Hippo and mouse models for cancer.- Roles of Hippo signaling during mouse embryogenesis.- Hippo Signaling and stem cells.- Hippo signaling and organ size control.- Hippo signaling in heart development.- Cell competition and the Hippo pathway.- Non-canonical roles from the Hippo pathway.- Index.