Main description:

medical research covered in thisvolume: epidemiology, physiologyand pathophysio logy, laboratory methodology, and renal pathology. New studies deal with the diagnosis and treatment of both incipient and overt nephropathy by metabolie, antihypertensive, and dietary invention. Considerable progress has been made in the management of end-stage renal failure and also in the management and treatment of nephropathy in the pregnant diabetic woman. Diabetic nephropathy is a worldwide problem, but it is more clearly defined in Europe and North America where facilities for the diagnosis and treatment of diabetes and its complications are readily available. Much more work needs to be done in other parts of the world, as it appears from this book. It is hoped that we now have a handbook for the kidney and hypertension in diabetes and that further progress can be made in clinical work in diagnosing and treating diabetic patients. Much more work still needs to be done regarding patient education with respect to complications. Many diabetics have now been trained to take part in the management of their metabolie control; they should also be trained to take part in the follow-up and treatment of complications. This volume also underlines the considerable need for future research. So far, research in this field has been carried out in relatively few countries and centers in the world. The editor is sure that this volume will also stimulate further advan cement in clinical science within the field of diabetic renal disease.

Contents:

Some Keys to the Literature. Prefaces. 1. Definition of diabetic renal disease in insulin-dependent diabetes mellitus based on renal function tests; C.E. Mogensen. 2. Albuminuria and renal disease in NIDDM-patients; A. Schmitz. 3. Familial factors in diabetic nephropathy; D.J. Pettitt, W.C. Knowler. 4. Hypertension, cardiovascular disease, diabetes mellitus, and diabetic nephropathy: role of insulin resistance; A. Solini, R.A. Defronzo. 5. Diabetes, hypertension, and kidney disease in the Pima Indians compared with other populations; W.C. Knowler, R.G. Nelson, D.J. Pettitt. 6. Economic evaluations of strategies for preventing renal disease in non-insulin dependent diabetes mellitus; D.L. Manninen, E.J. Dabach, F.B. Dong, R.E. Aubert, S.M. Teutsch, W.H. Herman. 7. Incidence of nephropathy in insulin-dependent diabetes mellitus as related to mortality and cost-benefit of early intervention; K. Borch-Johnsen. 8. Measurement of albumin and other urinary proteins in low concentration in diabetes mellitus: techniques and clinical significance; D.J.F. Rowe, W. Gatling. 9. Office tests for microalbuminuria; P.L. Poulsen. 10. Risk factor for progression of microalbuminuria in relatively young NIDDM-patients; R. Kikkawa, M. Haneda. 11. The clinical course of renal disease in caucausian NIDDM-patients; S. Nielsen, A. Schmitz. 12. Von Willebrand factor and the development of renal and vascular complications in diabetes; C.D.A. Stehouwer. 13. Smoking and diabetic nephropathy; P.T. Sawicki. 14. Light microscopy of diabetic glomerulopathy: the classic lesion; S. Olsen. 15. Haematuria and diabetic nephropathy; P. Kincaid-Smith, J.A. Whitworth. 16. Glomerular ultrastructural changes in microalbuminuric IDDM-patients; H.-J. Bangstad, R. Osterby. 17. Understanding of diabetic nephropathy from kidney and pancreas transplantation; P. Fioretto, M. Mauer. 18. Sodium-hydrogen antiport, cell function and susceptibility to diabetic nephropathy; R. Trevisan, G. Viberti. 19. Biochemical aspects of diabetic nephropathy; E.D. Schleicher. 20. The Steno hypothesis and glomerular basement membrane biochemistry in diabetic nephropathy; A. Kofoed-Enevoldsen. 21. Volume homeostasis and blood pressure in diabetic states; J.A. O'Hare, J.B. Ferriss. 22. Pathogenesis of diabetic glomerulopathy: the role of glomerular hemodynamic factors; J.P. Vora, S. Anderson, B.M. Brenner. 23. Roles of growth factors in diabetic kidney disease; A. Flyvbjerg, B. Nielsen, C. Skjaerbaek, J. Frystyk, H. Gronbaek, H. Orskov. 24. Blood pressure elevation in diabetes: results from 24-h ambulatory blood pressure recordings in diabetes; K.W. Hansen, P.L. Poulsen. 25. Insulin and blood pressure; R.O.B. Gans, A.J.M. Donker. 26. Cation transport, hypertension and diabetic nephropathy; R. Mangili. 27. Microalbuminuria in young patients with type I diabetes; H.B. Mortensen. 28. Early renal hyperfunction and hypertrophy in IDDM patients including comments on early intervention; M.M. Pedersen. 29. The concept of incipient diabetic nephropathy and effect