Main description:

This special volume of Progress in Molecular Biology and Translational Science focuses on the molecular biology of arrestins, with contributions from leaders in the field. Arrestins have emerged as central players in the regulation of many facets of G protein-coupled receptor signaling. This volume covers a variety of topics with reviews written by experts in the field.

Contents:

Part I: Perspective - The Duality of Arrestin Function

1. Arrestins Come of Age: A Personal Historical Perspective

Part II: The Molecular Biology of Arrestins

2. True Arrestins and Arrestin-Fold Proteins: A Structure-Based Appraisal

3. Structural Determinants of Arrestin Functions

4. Arrestins: Role in the Desensitization, Sequestration and Vesicular Trafficking of G Protein-Coupled Receptors

5. Arrestins as Regulators of Kinases and Phosphatases

6. ss-Arrestins: Modulators of Small GTPase Activation and Function

7. Arrestins and Protein Ubiquitination

8. Arrestins in Actin Reorganization and Cell Migration

Part III: The Physiological Roles of Arrestins

9. The Role of Arrestins in Development

10. The Role of Arrestins in Visual and Disease Processes of the Eye

11. b-Arrestins in the Central Nervous System

12. Arrestins in the Cardiovascular System

13. Arrestins in Bone

14. b-Arrestins in the Immune System

15. The Role of b-Arrestins in Cancer

16. Arrestins in Metabolic Regulation

Part IV: The Future - The Potential for Arrestin-based Therapeutics

17. Systems Analysis of Arrestin Pathway Functions

18. Arrestin Pathways as Drug Targets