Main description:

This comprehensive text provides a detailed overview of the molecular mechanisms underpinning the development of cancer and its treatment. Written by an international panel of researchers, specialists and practitioners in the field, the text discusses all aspects of cancer biology from the causes, development and diagnosis through to the treatment of cancer. * Written by an international panel of researchers, specialists and practitioners in the field * Covers both traditional areas of study and areas of controversy and emerging importance, highlighting future directions for research * Features up-to-date coverage of recent studies and discoveries, as well as a solid grounding in the key concepts in the field * Each chapter includes key points, chapter summaries, text boxes, and topical references for added comprehension and review * Supported by a dedicated website at www.blackwellpublishing.com/pelengaris * An excellent text for upper-level courses in the biology of cancer, for medical students and qualified practitioners preparing for higher exams, and for researchers and teachers in the field

Contents:

Preface. 1. Introduction: Stella Pelengaris & Mike Khan (both University of Warwick). 2. The Burden of Cancer: Will Steward & Anne Thomas (both University of Leicester). 3. Nature and Nurture in Oncogenesis: Stella Pelengaris & Mike Khan (both University of Warwick). 4. DNA Replication and the Cell Cycle: Stella Pelengaris & Mike Khan (both University of Warwick). 5. Regulation of Growth: Growth Factors, Receptors and Signaling Pathways: Stella Pelengaris & Mike Khan (both University of Warwick). 6. Oncogenes: Stella Pelengaris & Mike Khan (both University of Warwick). 7. Tumor Suppressor Genes: Martine Roussel (St. Jude's Children's Cancer Research Hospital). 8. Apoptosis: Stella Pelengaris & Mike Khan (both University of Warwick). 9. Telomeres and Senescence: Maria Blasco & Mike Khan (Spanish National Cancer Center, Madrid; University of Warwick). 10. Genetic Instability, Chromosomes, and Repair: Stella Pelengaris & Mike Khan (both University of Warwick). 11. Cancer is More Than a Genetic Condition: Stella Pelengaris & Mike Khan (both University of Warwick). 12. Cell-Matrix Adhesion, Cell-Cell Interactions and Malignancy: Charles Streuli (University of Manchester). 13. Tumor Immunity and Immunotherapy: Cassian Yee (Fred Hutchinson Cancer Research Center, University of Washington). 14. Angiogenesis: David T. Shima & Christiana Ruhrberg (Eyetech Research Center; University College of London). 15. Diagnosis of Cancer: Anne Thomas & Will Steward (both University of Leicester). 16. Treatment of Cancer: Chemotherapy and Radiotherapy: Anne Thomas (University of Leicester), R. A. Sharma (Royal Marsden Hospital, UK) and Will Steward (University of Leicester). 17. Caring For the Cancer Patient: Nicky Rudd & Esther Waterhouse (Both University Hospitals of Leicester and LOROS Hospice). 18. Genomics and Proteomics in Cancer Research and Diagnosis: Norbert C.J. de Wit (University of Warwick). Glossary. Index