Main description:

The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery.

With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development.

Contents:

Section 1 - General Aspects of Medicinal Chemistry
Section 2 - Lead Compound Discovery Strategies
Section 3 - Primary Exploration of Structure-Activity Relationships
Section 4 - Substituents and Functions: Qualitative and Quantitative Aspects of Structure-Activity Relationships
Section 5 - Spatial Organization, Receptor Mapping and Molecular Modeling
Section 6 - Chemical Modifications Influencing the Pharmacokinetic Properties
Section 7 - Pharmaceutical and Chemical Means to Solubility and Formulation Problems