Main description:

This volume of Progress in Molecular Biology and Translational Science discusses cutting-edge research of proteasomes and proteasome-associated proteins and cellular systems. The volume is split into two sections. The first part discusses the current knowledge of the structure, function, and regulation of the proteasomal system. The second part describes the role of the proteasome in aging and disease.

Contents:

Structure of the Proteasome
Tobias Jung and Tilman Grune

Structure and Function of the Ubiquitin-Proteasome System: Modulation of Components
Niki Chondrogianni and Efstathios S. Gonos

Immunoproteasomes: Structure, Function, and Antigen Presentation
Deborah A. Ferrington and Dale S. Gregerson

Interactions of the Proteasomal System with Chaperones - Protein Triage and Protein Quality Control
Marc Kastle and Tilman Grune

Proteasome Inhibitors
Boris Cvek

Degradation of Damaged Proteins - The Main Function of the 20S Proteasome
Andrew. M. Pickering and Kelvin. J. A. Davies

Changes of the Proteasomal System During the Aging Process
Martin A. Baraibar and Bertrand Friguet

Proteasome and Cancer
Betul Catalgol

The Ubiquitin Proteasome System and Cardiovascular Disease.
Saul R. Powell, Joerg Herrmann, Amir Lerman, Cam Patterson, Xuejun Wang

Role of the Ubiquitin-Proteasome in Protein Quality Control and Signaling: Implication in the Pathogenesis of Eye Diseases
Fu Shang and Allen Taylor

Proteasome and Neurodegenerative Diseases

Betul Catalgol and Tilman Grune