Main description:

This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights

Contents:

Section I: New Approaches to Studying UPR and Cell Stress

CFTR Expression Regulation by the Unfolded Protein Response Rafal Bartoszewski, Andras Rab, Lianwu Fu, Sylwia Bartoszewska, James Collawn and Zsuzsa Bebok
GRP78/BiP Chapter: Modulation of GRP78/BiP in Altering Sensitivity to Chemotherapy Thomas C. Chen
Targeting the Unfolded Protein Response in Cancer Therapy Marina V. Backer, Joseph M. Backer & Prakash Chinnaiyan
Large-scale analysis of UPR-mediated apoptosis in human cells Andrew M. Fribley, Justin R. Miller, Tyler E. Reist1, Michael U. Callaghan and Randal J. Kaufman
Quantitative Analysis of amino acid oxidation markers by tandem mass spectrometry Anuradha Vivekanandan-Giri, Jaeman Byun and Subramaniam Pennathur
Animal models in the study of the unfolded protein response Hemamalini Bommiasamy and Brian Popko
Measurement of Fluoride-induced Endoplasmic Reticulum Stress Using Gaussia luciferase Ramaswamy Sharma, Masahiro Tsuchiya, Bakhos A. Tannous and John D. Bartlett
Analysis of nelfinavir-induced endoplasmic reticulum stress Ansgar Bruning
Using temporal genetic switches to synchronize the unfolded protein response in cell populations in vivo Alexander Gow
Glycoprotein maturation and the UPR Andreas J. Hulsmeier, Michael Welti and Thierry Hennet
Monitoring and Manipulating Mammalian Unfolded Protein Response Nobuhiko Hiramatsu, Victory T. Joseph and Jonathan H. Lin
A screen for mutants requiring activation of the unfolded protein response for viability Guillaume Thibault and Davis T.W. Ng
Signalling Pathways of Proteostasis Network Unrevealed By Proteomic Approaches on The Understanding of Misfolded Protein Rescue Patricia Gomes-Alves, Sofia Neves and Deborah Penque
Decreased Secretion and Unfolded Protein Response Up-Regulation Carissa L. Young, Theresa Yuraszeck, Anne S. Robinson
Measuring signaling by the unfolded protein response David Cox, Natalie Strudwick, Ahmed A. Ali, Adrienne W. Paton, James C. Paton, and Martin Schroeder
Unfolded Protein Response Jie Shang
Regulation of immunoglobulin synthesis, modification and trafficking by the unfolded protein response: a quantitative approach Adi Drori and Boaz Tirosh
Use of Chemical Genomics in Assessment of the UPR Sakae Saito, Akihiro Tomida
Small GTPase signalling and the Unfolded Protein Response Marion Bouchecareilh, Esther Marza, Marie-Elaine Caruso and Eric Chevet
Inhibitors of advanced glycation and endoplasmic reticulum stress Reiko Inagi