Main description:

This textbook describes the basic principles of induced organ regeneration in skin and peripheral nerves and extends the original successful paradigm to other organs. A set of trans-organ rules is established and its use in regeneration of several organs is illustrated from the works of several independent investigators who worked with a variety of organs, such as the lung, the bladder, and the Achilles tendon, using collagen-based scaffolds somewhat similar to the original one. These critical medical treatments fill the clinical need that is not met by organ transplantation.

New to this second edition:

New information extending the paradigm of tissue regeneration from organ regeneration in skin and peripheral nerves to other organs

Guidelines, known as trans-organ rules, are described for the first time for extending this unique medical treatment to organs of several medical specialties

The work serves as a comprehensive text and reference for students and practitioners of tissue engineering

Contents:

The Irreversibility of Organ Injury.- Nonregenerative Tissues.- Experimental Methods I. The Anatomically Well-Defined Wound.- Experimental Methods II. The Defect Closure Rule.- Regeneration of Skin.- Regeneration of a Peripheral Nerve.- Minimum Reactants Required for Synthesis of Skin and Peripheral Nerves; Extension to Tissues of Other Organs.- An Antagonistic Relation Between Wound Contraction and Regeneration.- Molecular biology of contraction blockade by active scaffolds.- The Scaffold Regeneration Paradigm and its Consequences.