Main description:

G protein-coupled receptors (GPCRs) constitute the largest superfamily of cell surface receptors that regulate a variety of cell functions. Over the past few decades great progress has been made in defining the roles of intracellular trafficking in controlling the functionality of the receptors as well as in the development of various human diseases. This volume of Progress in Molecular Biology and Translational Science reviews the recent understanding of GPCR trafficking regulators and molecular mechanisms.

Contents:

Arrestins: Critical Players in Trafficking of Many GPCRs
Vsevolod V. Gurevich and Eugenia V. Gurevich
Regulation of GPCR Trafficking by Ubiquitin
Justine E. Kennedy and Adriano Marchese
Rhodopsin Trafficking and Mistrafficking: Signals, Molecular Components and Mechanisms
Ina Nemet, Philip Ropelewski and Yoshikazu Imanishi
Intracellular Trafficking of Neuropeptide Y Receptors
Karin Moerl and Annette G. Beck-Sickinger
Insights into Serotonin Receptor Trafficking: Cell Membrane Targeting and Internalization
Michele Darmon, Sana Al Awabdh , Michel-Boris Emerit and Justine Masson
Calcium-Sensing Receptor: Trafficking, Endocytosis, Recycling and Importance of Interacting Proteins
Kausik Ray
Trafficking of ss Adrenergic Receptors: Implications in Intracellular Receptor Signaling
Qin Fu and Yang K. Xiang
Post-endocytic sorting of Adrenergic and Opioid Receptors: New Mechanisms and Functions.
Shanna L. Bowman and Manojkumar A. Puthenveedu
a2 Adrenergic Receptor Trafficking as a Therapeutic Target in Antidepressant Drug Action
Christopher Cottingham, Craig J. Ferryman and Qin Wang
Regulation of a2B-Adrenerigc Receptor Export Trafficking by Specific Motifs
Guangyu Wu, Jason E. Davis and Maoxiang Zhang
Temperature-Sensitive Intracellular Traffic of ?2c-Adrenergic Receptor
Catalin M. Filipeanu
N-Terminal Signal Peptides of G Protein-Coupled Receptors: Significance for Receptor Biosynthesis, Trafficking and Signal Transduction
Claudia Rutz, Wolfgang Klein and Ralf Schulein
Regulation of GPCR Anterograde Trafficking by Molecular Chaperones and Motifs
Brent Young, Jaime Wertman and Denis J. Dupre