Main description:

The book will discuss the molecular mechanisms of cancer diseases, stem cell proliferation and transformation into cancer cells beyond the physiological processes that occur in normal stem cell biology. Some of the key oncogenic events in cancer and their signaling pathways that regulate cell division cycle progression will be described considering prospects for using such knowledge in advanced cancer therapy. Each chapter shall provide an invaluable resource for information on the most current advances in the field, with discussion of controversial issues and areas of emerging importance

Contents:

PART I Molecular Bases for Stem and Cancer Cells Proliferation

1 An introduction to proliferation and migration of stem cells
and cancer
Micheli Mainardi Pillat, Talita Glaser, Telma Tiemi Schwindt and Henning Ulrich

2 The role of cell adhesions, cell junctions and extracellular
matrix in normal development and carcinogenesis
Anderson K. Santos, Fernanda M. P. Tonelli, Daniel A. F. Silva, Katia N. Gomes, Luiz O. Ladeira and Rodrigo R. Resende

3 The embryonic rest hypothesis of cancer development:150
years later
Mariusz Z. Ratajczak, Maciej Tarnowski, Sylwia Borkowska, Karol Serwin.

4 Are calcium channels more important than calcium influx for cell proliferation ?
Anne-Sophie Borowiec, Gabriel Bidaux and Thierry Capiod

5 Role of calcium signaling in stem cells and cancer cells
proliferation
Maria Jimena Amaya, Vania A. M. Goulart, Anderson K. Santos, Alexandre H. Kihara, Silvia Guatimosim, Rodrigo R. Resende.

6 Formation and function of lipid droplets in inflammation
and cancer
Joao P.B. Viola, Andre L.S. Cruz, Miriam B.F. Werneck, Patricia T. Bozza

7 The role of sphingolipids in modulating pluripotency of stem
cells
Salman B. Hosain, Ronald A. Hill, Yong-Yu Liu

PART II Signaling Pathways to Cancer Cells Fate

8 Signaling pathways of cbl-b and its role on peripheral t cell
tolerance
K Venuprasad

9 BH3-only proteins in cancer and apoptosis
Fabio Ghiotto, Claudya Tenca, Franco Fais and Silvia Bruno

10 Signaling pathways of mta family proteins as regulators of
cancer progression and metastasis
Yasushi Toh, Garth L. Nicolson

11 Signalling pathways of -catenin/jnk on carcinogenesis
Eliana Kalakouti, Roya Babaei-Jadidi and Abdolrahman S. Nateri

12 The regulation of the jnk cascade and programmed cell death by
nf- b: mechanisms and functions
Jason Bennett, Marta Moretti, Anil K. Thotakura, Laura Tornatore and Guido Franzoso

PART III Uncontrolled Physiology Process Guiding to Cancer Cells

13 Migration, metastasis and more: the role of chemokines in the
proliferation, spreading and metastasis of tumors
Rolf Mentlein, Kirsten Hattermann and Janka Held-Feindt

14 Autophagy, cell death, and cancer
Maryam Mehrpour, Ahmed Hamai and Patrice Codogno

15 The duality of stem cells - double edged sword in tumour
evolution and treatment
Urska Tajnsek, Helena Motaln, Natasa Levicar, Ana Rotter and Tamara T.Lah

16 Glioblastoma stem cells and implications for chemoresistance
Suzana A. Kahn, Ema Torrado, Dora Brites, Vivaldo Moura Neto

17 The tumor microenvironment as a transient niche: a modulator of
epigenetic states and stem cell functions
Lorena E. Mora-Blanco, James B. Lorens, and Mark A. LaBarge

18 Tumor-associated neutrophils (tans)
Andre Gustavo Oliveira, Rodrigo Guabiraba, Mauro Martins Teixeira and Gustavo Batista Menezes

19 MicroRNA control of apoptotic programs in cancer
Reena V. Kartha and Subbaya Subramanian

PART IV Therapeutic Strategies for Anticancer Treatment

20 Markers of cancer stem cells and their functions
Olivier Gires

21 Cancer cell dormancy: potential therapeutic targets to eradicate
cancer cells within the niche
Jessian L.Munoz, Jacqueline M. Park, Sarah A. Bliss, Pranela Rameshwar

22 Modulating apoptosis in cancer therapy with ultrasound and high
intensity nanosecond electric pulses
Tinghe Yu, Minghe Wu, Ping Huang, Lina Hu

23 Targeting cell cycle for anticancer treatment and neuroprotection Yun Dai, Shuang Chen, Liang Yi, Minhui Xu