Main description:

The emphasis of this book is on mechanisms/pathways regulating the expression and actions of classical and novel tumor angiogenesis regulators, their underlying biology as well as anti-angiogenic drugs currently in use to fight different cancers. This book provides an insight on how factors such as obesity, diabetes and other metabolic disorders can influence the development and growth of cancer. It will be of interest not only to oncologists but also to a wide range of medical practitioners and researchers.

Contents:

VEGF Signaling in Normal and Tumor Angiogenesis. Regulation of Angiogenesis via Notch Signaling in Human Malignancy. Endothelial and Cancer Stem Cell Regulation of Tumor Angiogenesis. Differential Activation of Macrophages in Tumors: Roles in the Regulation of Tumor Development and Angiogenesis. Paracrine and Autocrine Control of Endothelial Cell Function by Inflammatory and Bioactive Lipid Mediators: Relevance for Tumor Angiogenesis. Tumor Angiogenesis Regulators in Breast Cancer: Does Race matter? Regulation of Tumor Angiogenesis by Non-Classical Factors: Peptide and Protein Factors, Lipid and Steroid Factors and by Other Novel Small Molecules. The Role of Cyclooxygenases and Lipoxygenases in the Regulation of Tumor Angiogenesis. Cathepsins and Other Proteases in Tumor Angiogenesis. Kruppel-like factor 5 (KLF5) and Tumor Angiogenesis. Signatures of Heightened Angiogenesis in Gynecologic Cancers: The Promise of Innovative Therapies. Obesity, Diabetes and Metabolic Syndrome Impact on Tumor Angiogenesis.