Main description:

This book discusses recent advances in biology, chemistry, and pharmacology at both the preclinical and clinical stage of transient receptor potential vanilloid subtype 1 (TRPV1) drug discovery research. Chapters explore the impact and drug targeting of TRPV1 in inflammation, migraine, arthritis, and cancer; as well as the development of analgesic drugs. The TRPV1 receptor is not limited to pain only, and the book covers its role in chronic cough, bladder disorders, and asthma. The book features data relevant to the therapeutic potential of TRPV1 and the medicinal chemistry involved in designing TRPV1 antagonists.

Contents:

Preface and Acknowledgments. Foreword. Contributors. PART I INTRODUCTION TO THE TRP CHANNELS. 1 TRP Channels and Human Diseases (Bernd Nilius and RudiVennekens). 2 Role of TRP Channels in Pain: An Overview (ArpadSzallasi). 3 Biochemical Pharmacology of TRPV1: Molecular Integrator ofPain Signals (Carol S. Surowy, Philip R. Kym, and Regina M.Reilly). 4 TRPV1 Genetics (Ruslan Dorfman, Hubert Tsui, Michael W.Salter, and H.-Michael Dosch). PART II ROLE FOR TRPV1 IN PAIN STATES. 5 TRPV1 and Inflammatory Pain (Anindya Bhattacharya, Sonya G.Lehto, and Narender R. Gavva). 6 Role of TRPV1 Receptors in Osteoarthritic Pain (Shailen K.Joshi and Prisca Honore). 7 TRPV1 and Bone Cancer Pain (Juan Miguel Jimenez-Andrade andPatrick Mantyh). 8 TRPV1 in Visceral Pain and Other Visceral Disorders(Antonio Avelino and Francisco Cruz). 9 TRPV1 Receptors and Migraine (Philip R. Holland and PeterJ. Goadsby). 10 TRPV1 in Neuropathic Pain and Neurological andNeuropsychiatric Disorders (Enza Palazzo, Katarzyna Starowicz,Sabatino Maione, and Vincenzo Di Marzo). PART III TRPV1 ANTAGONISTS AND AGONISTS AS NOVEL ANALGESICDRUGS. 11 Aryl-Urea Class and Related TRPV1 Antagonists (ArthurGomtsyan). 12 2-Pyridinylpiperazine Carboxamide Class and Related TRPV1Antagonists (Natalie A. Hawryluk and Nicholas I.Carruthers). 13 TRPV1 Agonist Approaches for Pain Management (Keith R.Bley). PART IV ROLE FOR TRPV1 IN OTHER PHYSIOLOGICAL PROCESSESBESIDES PAIN TRANSMISSION. 14 The TRPV1 Channel in Normal Thermoregulation: What Have WeLearned from Experiments Using Different Tools? (Andras Garami,Maria C. Almeida, Tatiane B. Nucci, Tamara Hew-Butler, Renato N.Soriano, Eszter Pakai, Kazuhiro Nakamura, Shaun F. Morrison, andAndrej A. Romanovsky). 15 The Role of TRPV1 in Respiratory Diseases (SerenaMaterazzi, Alain Tchoimou, Romina Nassini, Marcello Trevisani, andPierangelo Geppetti). 16 The Role of TRPV1 in Diabetes (Hubert Tsui, RuslanDorfman, Michael W. Salter, and H.-Michael Dosch). Afterword. Index.