Main description:

Viral Gastroenteritis: Molecular Epidemiology and Pathogenesis provides a comprehensive review of research on viruses causing acute gastroenteritis in infants and young children, including coverage of rotaviruses, human caliciviruses, astroviruses, enteric adenoviruses, and viruses causing gastroenteritis more rarely. Includes general chapters on gastrointestinal physiology and pathophysiology, gastrointestinal immune mechanisms, immunodeficiencies and host genetics influencing susceptibility to viral gastroenteritis, and therapeutic and preventative approaches.

The book also includes special sections on virus particle structures, replication cycles, pathogenesis, immunology, epidemiology, and preventative measures. This book covers both basic science and translational applications and is an appropriate resource for virologists, molecular biologists, epidemiologists, gastroenterologists, vaccinologists, and those with an interest in public health.

Contents:

1. Gastrointestinal physiology and pathophysiology
2. Gastrointestinal immunity
3. Host genetics and susceptibility to gastrointestinal infections
4. Immunodeficiencies, in particular IgA deficiency
5. Metagenomics of viruses infecting the gut
6. Gut microbiota and disease
7. Therapy of gastroenteritis
8. Rotavirus
9. Structure function
10. Replication (4-5 chapters)
11. Pathogenesis (2 chapters)
12. Immunology (2 chapters)
13. Molecular epidemiology and evolution
14. Vaccine and therapeutic developments and implementation (2 chapters)
- Human caliciviruses
- Structure function
- Replication (2 chapters)
- Animal models
- Epidemiology and evolution (2 chapters)
- Vaccine development
- Astroviruses
- Structure function
- Replication (2 chapters)
- Epidemiology
- Other viruses causing gastroenteritis
- Aichi virus
- Enteroviruses
- Picobirnavirus