Main description:

Internationally recognized scientists, clinicians, and technologists review and explain the fundamental molecular and cellular biology that has been applied to the emerging field of transplant immunology and xenotransplantation, and what impact these advances might optimally have on medicine and science. The authoritative experts writing here-many of whom made the basic discoveries underlying the recent advances-examine the biological and immunological hurdles to xenotransplantation, illuminating how the immune system interacts with the xenograft and laying a practical foundation for the use of genetic engineering and animal transplants in the treatment of human disease.

Contents:

Molecular and Cellular Hurdles to Xenotransplantation
Jeffrey L. Platt

Pathological Responses to Xenotransplantation
Matilde Bustos and Jeffrey L. Platt

Natural Xenoreactive Antibodies
Uri Galili

Specificity of Xenoreactive Natural Antibodies
William Parker, Paul B. Yu, and Yuko C. Nakamura

Biophysical Properties of Xenoreactive Natural Antibodies
William Parker, Ryan C. Fields, and Yuko C. Nakamura

The Origin of Xenoreactive Natural Antibodies
Paul B. Yu

Synthesis of Carbohydrate Antigens Recognized by Xenoreactive Antibodies
Mauro S. Sandrin and Ian F. C. McKenzie

The Complement Barrier to Xenotransplantation
Agustin P. Dalmasso

Defects and Amplification of Costimulation Across the Species
Nicola Rogers and Robert Lechler

Antibody-Dependent Effects on Cellular Immunity
Antonello Pileggi, R. Damaris Molano, Thierry Berney, and Luca Inverardi

Disordered Regulation of Coagulation and Platelet Activation in Xenotransplantation
Simon C. Robson

Current Applications of Cellular Xenografts
Albert S. B. Edge

Index